Weight Change and Incident Distal Colorectal Adenoma Risk in the PLCO Cancer Screening Trial.
Date
2022-02-01Journal
JNCI Cancer SpectrumPublisher
Oxford University PressType
Article
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Compared with stable weight, weight loss during early-late adulthood was associated with reduced adenoma risk (OR = 0.54, 95% CI = 0.34 to 0.86), particularly among those who were overweight or obese at age 20 years (OR = 0.39, 95% CI = 0.18 to 0.84). Results were similar for early-middle adulthood but less pronounced for middle-late adulthood. Weight gain greater than 3 kg/5 years during early-late adulthood was associated with increased risk (OR = 1.30, 95% CI = 1.07 to 1.58, P trend < .001). Findings appeared stronger among men (OR for >3 kg/5 years = 1.41, 95% CI = 1.11 to 1.80) than women (OR = 1.09, 95% CI = 0.79 to 1.50, P interaction = .21).Rights/Terms
© The Author(s) 2022. Published by Oxford University Press.Identifier to cite or link to this item
http://hdl.handle.net/10713/17873ae974a485f413a2113503eed53cd6c53
10.1093/jncics/pkab098
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