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    Adenovirus-based vaccines - a platform for pandemic preparedness against emerging viral pathogens.

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    Author
    Coughlan, Lynda
    Kremer, Eric J
    Shayakhmetov, Dmitry M
    Date
    2022-01-26
    Journal
    Molecular Therapy
    Publisher
    Elsevier
    Type
    Article
    
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    Show full item record
    See at
    https://doi.org/10.1016/j.ymthe.2022.01.034
    https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/35092844/
    Abstract
    Zoonotic viruses continually pose a pandemic threat. Infection of humans with viruses for which we typically have little or no prior immunity, can result in epidemics with high morbidity and mortality. These epidemics can have public health and economic impact, and can exacerbate civil unrest or political instability. Changes in human behavior in the past few decades: increased global travel, farming intensification, the exotic animal trade, as well as the impact of global warming on animal migratory patterns, habitats and ecosystems, contribute to the increased frequency of cross-species transmission events. Investing in the pre-clinical advancement of vaccine candidates against diverse emerging viral threats is crucial for pandemic preparedness. Replication-defective adenoviral (Ad) vectors have demonstrated their utility as an outbreak-responsive vaccine platform during the SARS-CoV-2 pandemic. Ad vectors are easy to engineer, are amenable to rapid, inexpensive manufacturing, are relatively safe and immunogenic in humans, and importantly, and do not require specialized cold-chain storage, making them an ideal platform for equitable global distribution, or stockpiling. In this review, we discuss the progress in applying Ad-based vaccines against emerging viruses, and summarize their global safety profile, as reflected by their widespread geographic use during the SARS-CoV-2 pandemic.
    Rights/Terms
    Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
    Keyword
    Adenovirus
    emerging
    outbreak
    pandemic
    pathogen
    vaccine
    vector
    virus
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17846
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ymthe.2022.01.034
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    UMB Coronavirus Publications
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