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    The Impact of Age and BMI on the VWF/ADAMTS13 Axis and Simultaneous Thrombin and Plasmin Generation in Hospitalized COVID-19 Patients.

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    Author
    Thangaraju, Kiruphagaran
    Katneni, Upendra
    Akpan, Imo J
    Tanaka, Kenichi
    Thomas, Tiffany
    Setua, Saini
    Reisz, Julie A
    Cendali, Francesca
    Gamboni, Fabia
    Nemkov, Travis
    Kahn, Stacie
    Wei, Alexander Z
    Valk, Jacob E
    Hudson, Krystalyn E
    Roh, David J
    Moriconi, Chiara
    Zimring, James C
    D'Alessandro, Angelo
    Spitalnik, Steven L
    Francis, Richard O
    Buehler, Paul W
    Show allShow less

    Date
    2022-01-10
    Journal
    Frontiers in Medicine
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fmed.2021.817305
    Abstract
    Aging and obesity independently contribute toward an endothelial dysfunction that results in an imbalanced VWF to ADAMTS13 ratio. In addition, plasma thrombin and plasmin generation are elevated and reduced, respectively, with increasing age and also with increasing body mass index (BMI). The severity risk of Corona Virus Disease 2019 (COVID-19) increases in adults older than 65 and in individuals with certain pre-existing health conditions, including obesity (>30 kg/m2). The present cross-sectional study focused on an analysis of the VWF/ADAMTS13 axis, including measurements of von Willebrand factor (VWF) antigen (VWF:AG), VWF collagen binding activity (VWF:CBA), Factor VIII antigen, ADAMTS13 antigen, and ADAMTS13 activity, in addition to thrombin and plasmin generation potential, in a demographically diverse population of COVID-19 negative (-) (n = 288) and COVID-19 positive (+) (n = 543) patient plasmas collected at the time of hospital presentation. Data were analyzed as a whole, and then after dividing patients by age (<65 and ≥65) and independently by BMI [<18.5, 18.5-24.9, 25-29.9, >30 (kg/m2)]. These analyses suggest that VWF parameters (i.e., the VWF/ADAMTS13 activity ratio) and thrombin and plasmin generation differed in COVID-19 (+), as compared to COVID-19 (-) patient plasma. Further, age (≥65) more than BMI contributed to aberrant plasma indicators of endothelial coagulopathy. Based on these findings, evaluating both the VWF/ADAMTS13 axis, along with thrombin and plasmin generation, could provide insight into the extent of endothelial dysfunction as well as the plasmatic imbalance in coagulation and fibrinolysis potential, particularly for at-risk patient populations.
    Rights/Terms
    Copyright © 2022 Thangaraju, Katneni, Akpan, Tanaka, Thomas, Setua, Reisz, Cendali, Gamboni, Nemkov, Kahn, Wei, Valk, Hudson, Roh, Moriconi, Zimring, D'Alessandro, Spitalnik, Francis and Buehler.
    Keyword
    ADAMTS13
    COVID-19
    plasmin
    thrombin
    von Willebrand factor
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17845
    ae974a485f413a2113503eed53cd6c53
    10.3389/fmed.2021.817305
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles

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