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    Effective Barriers: The Role of NKT Cells and Innate Lymphoid Cells in the Gut.

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    Author
    Cairo, Cristiana
    Webb, Tonya J
    Date
    2022-01-15
    Journal
    Journal of Immunology (Baltimore, Md. : 1950)
    Publisher
    American Association of Immunologists
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.4049/jimmunol.2100799
    Abstract
    The critical role of commensal microbiota in regulating the host immune response has been established. In addition, it is known that host-microbial interactions are bidirectional, and this interplay is tightly regulated to prevent chronic inflammatory disease. Although many studies have focused on the role of classic T cell subsets, unconventional lymphocytes such as NKT cells and innate lymphoid cells also contribute to the regulation of homeostasis at mucosal surfaces and influence the composition of the intestinal microbiota. In this review, we discuss the mechanisms involved in the cross-regulation between NKT cells, innate lymphoid cells, and the gut microbiota. Moreover, we highlight how disruptions in homeostasis can lead to immune-mediated disorders.
    Rights/Terms
    Copyright © 2022 by The American Association of Immunologists, Inc.
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17844
    ae974a485f413a2113503eed53cd6c53
    10.4049/jimmunol.2100799
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