Effective Barriers: The Role of NKT Cells and Innate Lymphoid Cells in the Gut.
Date
2022-01-15Journal
Journal of Immunology (Baltimore, Md. : 1950)Publisher
American Association of ImmunologistsType
Article
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The critical role of commensal microbiota in regulating the host immune response has been established. In addition, it is known that host-microbial interactions are bidirectional, and this interplay is tightly regulated to prevent chronic inflammatory disease. Although many studies have focused on the role of classic T cell subsets, unconventional lymphocytes such as NKT cells and innate lymphoid cells also contribute to the regulation of homeostasis at mucosal surfaces and influence the composition of the intestinal microbiota. In this review, we discuss the mechanisms involved in the cross-regulation between NKT cells, innate lymphoid cells, and the gut microbiota. Moreover, we highlight how disruptions in homeostasis can lead to immune-mediated disorders.Rights/Terms
Copyright © 2022 by The American Association of Immunologists, Inc.Identifier to cite or link to this item
http://hdl.handle.net/10713/17844ae974a485f413a2113503eed53cd6c53
10.4049/jimmunol.2100799
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