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dc.contributor.authorBembea, Melania M
dc.contributor.authorAgus, Michael
dc.contributor.authorAkcan-Arikan, Ayse
dc.contributor.authorAlexander, Peta
dc.contributor.authorBasu, Rajit
dc.contributor.authorBennett, Tellen D
dc.contributor.authorBohn, Desmond
dc.contributor.authorBrandão, Leonardo R
dc.contributor.authorBrown, Ann-Marie
dc.contributor.authorCarcillo, Joseph A
dc.contributor.authorChecchia, Paul
dc.contributor.authorCholette, Jill
dc.contributor.authorCheifetz, Ira M
dc.contributor.authorCornell, Timothy
dc.contributor.authorDoctor, Allan
dc.contributor.authorEckerle, Michelle
dc.contributor.authorErickson, Simon
dc.contributor.authorFarris, Reid W D
dc.contributor.authorFaustino, E Vincent S
dc.contributor.authorFitzgerald, Julie C
dc.contributor.authorFuhrman, Dana Y
dc.contributor.authorGiuliano, John S
dc.contributor.authorGuilliams, Kristin
dc.contributor.authorGaies, Michael
dc.contributor.authorGorga, Stephen M
dc.contributor.authorHall, Mark
dc.contributor.authorHanson, Sheila J
dc.contributor.authorHartman, Mary
dc.contributor.authorHassinger, Amanda B
dc.contributor.authorIrving, Sharon Y
dc.contributor.authorJeffries, Howard
dc.contributor.authorJouvet, Philippe
dc.contributor.authorKannan, Sujatha
dc.contributor.authorKaram, Oliver
dc.contributor.authorKhemani, Robinder G
dc.contributor.authorKissoon, Niranjan
dc.contributor.authorLacroix, Jacques
dc.contributor.authorLaussen, Peter
dc.contributor.authorLeclerc, Francis
dc.contributor.authorLee, Jan Hau
dc.contributor.authorLeteurtre, Stephane
dc.contributor.authorLobner, Katie
dc.contributor.authorMcKiernan, Patrick J
dc.contributor.authorMenon, Kusum
dc.contributor.authorMonagle, Paul
dc.contributor.authorMuszynski, Jennifer A
dc.contributor.authorOdetola, Folafoluwa
dc.contributor.authorParker, Robert
dc.contributor.authorPathan, Nazima
dc.contributor.authorPierce, Richard W
dc.contributor.authorPineda, Jose
dc.contributor.authorPrince, Jose M
dc.contributor.authorRobinson, Karen A
dc.contributor.authorRowan, Courtney M
dc.contributor.authorRyerson, Lindsay M
dc.contributor.authorSanchez-Pinto, L Nelson
dc.contributor.authorSchlapbach, Luregn J
dc.contributor.authorSelewski, David T
dc.contributor.authorShekerdemian, Lara S
dc.contributor.authorSimon, Dennis
dc.contributor.authorSmith, Lincoln S
dc.contributor.authorSquires, James E
dc.contributor.authorSquires, Robert H
dc.contributor.authorSutherland, Scott M
dc.contributor.authorOuellette, Yves
dc.contributor.authorSpaeder, Michael C
dc.contributor.authorSrinivasan, Vijay
dc.contributor.authorSteiner, Marie E
dc.contributor.authorTasker, Robert C
dc.contributor.authorThiagarajan, Ravi
dc.contributor.authorThomas, Neal
dc.contributor.authorTissieres, Pierre
dc.contributor.authorTraube, Chani
dc.contributor.authorTucci, Marisa
dc.contributor.authorTyppo, Katri V
dc.contributor.authorWainwright, Mark S
dc.contributor.authorWard, Shan L
dc.contributor.authorWatson, R Scott
dc.contributor.authorWeiss, Scott
dc.contributor.authorWhitney, Jane
dc.contributor.authorWillson, Doug
dc.contributor.authorWynn, James L
dc.contributor.authorYeyha, Nadir
dc.contributor.authorZimmerman, Jerry J
dc.date.accessioned2022-01-26T14:20:20Z
dc.date.available2022-01-26T14:20:20Z
dc.date.issued2022-01
dc.identifier.urihttp://hdl.handle.net/10713/17789
dc.description.abstractPrior criteria for organ dysfunction in critically ill children were based mainly on expert opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) expert panel to summarize data characterizing single and multiple organ dysfunction and to derive contemporary criteria for pediatric organ dysfunction. The panel was composed of 88 members representing 47 institutions and 7 countries. We conducted systematic reviews of the literature to derive evidence-based criteria for single organ dysfunction for neurologic, cardiovascular, respiratory, gastrointestinal, acute liver, renal, hematologic, coagulation, endocrine, endothelial, and immune system dysfunction. We searched PubMed and Embase from January 1992 to January 2020. Study identification was accomplished using a combination of medical subject headings terms and keywords related to concepts of pediatric organ dysfunction. Electronic searches were performed by medical librarians. Studies were eligible for inclusion if the authors reported original data collected in critically ill children; evaluated performance characteristics of scoring tools or clinical assessments for organ dysfunction; and assessed a patient-centered, clinically meaningful outcome. Data were abstracted from each included study into an electronic data extraction form. Risk of bias was assessed using the Quality in Prognosis Studies tool. Consensus was achieved for a final set of 43 criteria for pediatric organ dysfunction through iterative voting and discussion. Although the PODIUM criteria for organ dysfunction were limited by available evidence and will require validation, they provide a contemporary foundation for researchers to identify and study single and multiple organ dysfunction in critically ill children.en_US
dc.description.urihttps://doi.org/10.1542/peds.2021-052888Ben_US
dc.language.isoenen_US
dc.publisherAmerican Academy of Pediatricsen_US
dc.relation.ispartofPediatricsen_US
dc.rightsCopyright © 2022 by the American Academy of Pediatrics.en_US
dc.titlePediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.en_US
dc.typeArticleen_US
dc.identifier.doi10.1542/peds.2021-052888B
dc.identifier.pmid34970673
dc.source.journaltitlePediatrics
dc.source.volume149
dc.source.issueSupplement_1
dc.source.beginpageS1
dc.source.endpageS12
dc.source.countryUnited States


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