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    Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.

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    Author
    Bembea, Melania M
    Agus, Michael
    Akcan-Arikan, Ayse
    Alexander, Peta
    Basu, Rajit
    Bennett, Tellen D
    Bohn, Desmond
    Brandão, Leonardo R
    Brown, Ann-Marie
    Carcillo, Joseph A
    Checchia, Paul
    Cholette, Jill
    Cheifetz, Ira M
    Cornell, Timothy
    Doctor, Allan
    Eckerle, Michelle
    Erickson, Simon
    Farris, Reid W D
    Faustino, E Vincent S
    Fitzgerald, Julie C
    Fuhrman, Dana Y
    Giuliano, John S
    Guilliams, Kristin
    Gaies, Michael
    Gorga, Stephen M
    Hall, Mark
    Hanson, Sheila J
    Hartman, Mary
    Hassinger, Amanda B
    Irving, Sharon Y
    Jeffries, Howard
    Jouvet, Philippe
    Kannan, Sujatha
    Karam, Oliver
    Khemani, Robinder G
    Kissoon, Niranjan
    Lacroix, Jacques
    Laussen, Peter
    Leclerc, Francis
    Lee, Jan Hau
    Leteurtre, Stephane
    Lobner, Katie
    McKiernan, Patrick J
    Menon, Kusum
    Monagle, Paul
    Muszynski, Jennifer A
    Odetola, Folafoluwa
    Parker, Robert
    Pathan, Nazima
    Pierce, Richard W
    Pineda, Jose
    Prince, Jose M
    Robinson, Karen A
    Rowan, Courtney M
    Ryerson, Lindsay M
    Sanchez-Pinto, L Nelson
    Schlapbach, Luregn J
    Selewski, David T
    Shekerdemian, Lara S
    Simon, Dennis
    Smith, Lincoln S
    Squires, James E
    Squires, Robert H
    Sutherland, Scott M
    Ouellette, Yves
    Spaeder, Michael C
    Srinivasan, Vijay
    Steiner, Marie E
    Tasker, Robert C
    Thiagarajan, Ravi
    Thomas, Neal
    Tissieres, Pierre
    Traube, Chani
    Tucci, Marisa
    Typpo, Katri V
    Wainwright, Mark S
    Ward, Shan L
    Watson, R Scott
    Weiss, Scott
    Whitney, Jane
    Willson, Doug
    Wynn, James L
    Yeyha, Nadir
    Zimmerman, Jerry J
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    Date
    2022-01
    Journal
    Pediatrics
    Publisher
    American Academy of Pediatrics
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1542/peds.2021-052888B
    Abstract
    Prior criteria for organ dysfunction in critically ill children were based mainly on expert opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) expert panel to summarize data characterizing single and multiple organ dysfunction and to derive contemporary criteria for pediatric organ dysfunction. The panel was composed of 88 members representing 47 institutions and 7 countries. We conducted systematic reviews of the literature to derive evidence-based criteria for single organ dysfunction for neurologic, cardiovascular, respiratory, gastrointestinal, acute liver, renal, hematologic, coagulation, endocrine, endothelial, and immune system dysfunction. We searched PubMed and Embase from January 1992 to January 2020. Study identification was accomplished using a combination of medical subject headings terms and keywords related to concepts of pediatric organ dysfunction. Electronic searches were performed by medical librarians. Studies were eligible for inclusion if the authors reported original data collected in critically ill children; evaluated performance characteristics of scoring tools or clinical assessments for organ dysfunction; and assessed a patient-centered, clinically meaningful outcome. Data were abstracted from each included study into an electronic data extraction form. Risk of bias was assessed using the Quality in Prognosis Studies tool. Consensus was achieved for a final set of 43 criteria for pediatric organ dysfunction through iterative voting and discussion. Although the PODIUM criteria for organ dysfunction were limited by available evidence and will require validation, they provide a contemporary foundation for researchers to identify and study single and multiple organ dysfunction in critically ill children.
    Rights/Terms
    Copyright © 2022 by the American Academy of Pediatrics.
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17789
    ae974a485f413a2113503eed53cd6c53
    10.1542/peds.2021-052888B
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