Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.
Author
Bembea, Melania MAgus, Michael
Akcan-Arikan, Ayse
Alexander, Peta
Basu, Rajit
Bennett, Tellen D
Bohn, Desmond
Brandão, Leonardo R
Brown, Ann-Marie
Carcillo, Joseph A
Checchia, Paul
Cholette, Jill
Cheifetz, Ira M
Cornell, Timothy
Doctor, Allan
Eckerle, Michelle
Erickson, Simon
Farris, Reid W D
Faustino, E Vincent S
Fitzgerald, Julie C
Fuhrman, Dana Y
Giuliano, John S
Guilliams, Kristin
Gaies, Michael
Gorga, Stephen M
Hall, Mark
Hanson, Sheila J
Hartman, Mary
Hassinger, Amanda B
Irving, Sharon Y
Jeffries, Howard
Jouvet, Philippe
Kannan, Sujatha
Karam, Oliver
Khemani, Robinder G
Kissoon, Niranjan
Lacroix, Jacques
Laussen, Peter
Leclerc, Francis
Lee, Jan Hau
Leteurtre, Stephane
Lobner, Katie
McKiernan, Patrick J
Menon, Kusum
Monagle, Paul
Muszynski, Jennifer A
Odetola, Folafoluwa
Parker, Robert
Pathan, Nazima
Pierce, Richard W
Pineda, Jose
Prince, Jose M
Robinson, Karen A
Rowan, Courtney M
Ryerson, Lindsay M
Sanchez-Pinto, L Nelson
Schlapbach, Luregn J
Selewski, David T
Shekerdemian, Lara S
Simon, Dennis
Smith, Lincoln S
Squires, James E
Squires, Robert H
Sutherland, Scott M
Ouellette, Yves
Spaeder, Michael C
Srinivasan, Vijay
Steiner, Marie E
Tasker, Robert C
Thiagarajan, Ravi
Thomas, Neal
Tissieres, Pierre
Traube, Chani
Tucci, Marisa
Typpo, Katri V
Wainwright, Mark S
Ward, Shan L
Watson, R Scott
Weiss, Scott
Whitney, Jane
Willson, Doug
Wynn, James L
Yeyha, Nadir
Zimmerman, Jerry J
Date
2022-01Journal
PediatricsPublisher
American Academy of PediatricsType
Article
Metadata
Show full item recordAbstract
Prior criteria for organ dysfunction in critically ill children were based mainly on expert opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) expert panel to summarize data characterizing single and multiple organ dysfunction and to derive contemporary criteria for pediatric organ dysfunction. The panel was composed of 88 members representing 47 institutions and 7 countries. We conducted systematic reviews of the literature to derive evidence-based criteria for single organ dysfunction for neurologic, cardiovascular, respiratory, gastrointestinal, acute liver, renal, hematologic, coagulation, endocrine, endothelial, and immune system dysfunction. We searched PubMed and Embase from January 1992 to January 2020. Study identification was accomplished using a combination of medical subject headings terms and keywords related to concepts of pediatric organ dysfunction. Electronic searches were performed by medical librarians. Studies were eligible for inclusion if the authors reported original data collected in critically ill children; evaluated performance characteristics of scoring tools or clinical assessments for organ dysfunction; and assessed a patient-centered, clinically meaningful outcome. Data were abstracted from each included study into an electronic data extraction form. Risk of bias was assessed using the Quality in Prognosis Studies tool. Consensus was achieved for a final set of 43 criteria for pediatric organ dysfunction through iterative voting and discussion. Although the PODIUM criteria for organ dysfunction were limited by available evidence and will require validation, they provide a contemporary foundation for researchers to identify and study single and multiple organ dysfunction in critically ill children.Rights/Terms
Copyright © 2022 by the American Academy of Pediatrics.Identifier to cite or link to this item
http://hdl.handle.net/10713/17789ae974a485f413a2113503eed53cd6c53
10.1542/peds.2021-052888B
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