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    Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.

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    Author
    Muszynski, Jennifer A
    Cholette, Jill M
    Steiner, Marie E
    Tucci, Marisa
    Doctor, Allan
    Parker, Robert I
    Date
    2022-01
    Journal
    Pediatrics
    Publisher
    American Academy of Pediatrics
    Type
    Article
    
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    Show full item record
    See at
    https://doi.org/10.1542/peds.2021-052888K
    Abstract
    CONTEXT: Studies of organ dysfunction in children are limited by a lack of consensus around organ dysfunction criteria. OBJECTIVES: To derive evidence-informed, consensus-based criteria for hematologic dysfunction in critically ill children. DATA SOURCES: Data sources included PubMed and Embase from January 1992 to January 2020. STUDY SELECTION: Studies were included if they evaluated assessment/scoring tools to screen for hematologic dysfunction and assessed outcomes of mortality, functional status, organ-specific outcomes, or other patient-centered outcomes. Studies of adults or premature infants, animal studies, reviews/commentaries, small case series, and non-English language studies with inability to determine eligibility were excluded. DATA EXTRACTION: Data were abstracted from each eligible study into a standard data extraction form along with risk of bias assessment. RESULTS: Twenty-nine studies were included. The systematic review supports the following criteria for hematologic dysfunction: thrombocytopenia (platelet count <100000 cells/µL in patients without hematologic or oncologic diagnosis, platelet count <30000 cells/µL in patients with hematologic or oncologic diagnoses, or platelet count decreased ≥50% from baseline; or leukocyte count <3000 cells/µL; or hemoglobin concentration between 5 and 7 g/dL (nonsevere) or <5 g/dL (severe). LIMITATIONS: Most studies evaluated pre-specified thresholds of cytopenias. No studies addressed associations between the etiology or progression of cytopenias overtime with outcomes, and no studies evaluated cellular function. CONCLUSIONS: Hematologic dysfunction, as defined by cytopenia, is a risk factor for poor outcome in critically ill children, although specific threshold values associated with increased mortality are poorly defined by the current literature.
    Rights/Terms
    Copyright © 2022 by the American Academy of Pediatrics.
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17788
    ae974a485f413a2113503eed53cd6c53
    10.1542/peds.2021-052888K
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