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    Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries.

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    Author
    Shakya, Mila
    Neuzil, Kathleen M
    Pollard, Andrew J
    Journal
    Journal of Infectious Diseases
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/infdis/jiab393
    http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8687069/
    Abstract
    Low- and middle-income countries face a high burden of typhoid and paratyphoid fever due to poor water quality and inadequate sanitation. The World Health Organization (WHO) recommends the use of typhoid conjugate vaccines (TCV) in endemic settings and Gavi, the Vaccine Alliance, supports TCV introduction. There are currently 2 WHO-prequalified TCVs with Typbar TCV introduced in Pakistan, Liberia, and Zimbabwe. Countries should assess disease burden and consider introduction of TCV for programmatic use. Several paratyphoid vaccine candidates are in early stages of development. An effective bivalent vaccine would be the most efficient way to control typhoid and paratyphoid fever.
    Rights/Terms
    © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.
    Keyword
    paratyphoid fever
    typhoid conjugate vaccines
    typhoid fever
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17761
    ae974a485f413a2113503eed53cd6c53
    10.1093/infdis/jiab393
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