Prospects of Future Typhoid and Paratyphoid Vaccines in Endemic Countries.
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Journal of Infectious DiseasesPublisher
Oxford University PressType
Article
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Low- and middle-income countries face a high burden of typhoid and paratyphoid fever due to poor water quality and inadequate sanitation. The World Health Organization (WHO) recommends the use of typhoid conjugate vaccines (TCV) in endemic settings and Gavi, the Vaccine Alliance, supports TCV introduction. There are currently 2 WHO-prequalified TCVs with Typbar TCV introduced in Pakistan, Liberia, and Zimbabwe. Countries should assess disease burden and consider introduction of TCV for programmatic use. Several paratyphoid vaccine candidates are in early stages of development. An effective bivalent vaccine would be the most efficient way to control typhoid and paratyphoid fever.Rights/Terms
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.Identifier to cite or link to this item
http://hdl.handle.net/10713/17761ae974a485f413a2113503eed53cd6c53
10.1093/infdis/jiab393
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