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dc.contributor.authorFink, Ericka L.
dc.contributor.authorRobertson, Courtney L.
dc.contributor.authorWainwright, Mark S.
dc.contributor.authorRoa, Juan D.
dc.contributor.authorLovett, Marlina E.
dc.contributor.authorStulce, Casey
dc.contributor.authorYacoub, Mais
dc.contributor.authorPotera, Renee M.
dc.contributor.authorZivick, Elizabeth
dc.contributor.authorHolloway, Adrian
dc.contributor.authorNagpal, Ashish
dc.contributor.authorWellnitz, Kari
dc.contributor.authorCzech, Theresa
dc.contributor.authorEven, Katelyn M.
dc.contributor.authorBrunow de Carvalho, Werther
dc.contributor.authorRodriguez, Isadora Souza
dc.contributor.authorSchwartz, Stephanie P.
dc.contributor.authorWalker, Tracie C.
dc.contributor.authorCampos-Miño, Santiago
dc.contributor.authorDervan, Leslie A.
dc.contributor.authorGeneslaw, Andrew S.
dc.contributor.authorSewell, Taylor B.
dc.contributor.authorPryce, Patrice
dc.contributor.authorSilver, Wendy G.
dc.contributor.authorLin, Jieru Egeria
dc.contributor.authorVargas, Wendy S.
dc.contributor.authorTopjian, Alexis
dc.contributor.authorAlcamo, Alicia M.
dc.contributor.authorMcGuire, Jennifer L.
dc.contributor.authorDomínguez Rojas, Jesus Angel
dc.contributor.authorMuñoz, Jaime Tasayco
dc.contributor.authorHong, Sue J.
dc.contributor.authorMuller, William J.
dc.contributor.authorDoerfler, Matthew
dc.contributor.authorWilliams, Cydni N.
dc.contributor.authorDrury, Kurt
dc.contributor.authorBhagat, Dhristie
dc.contributor.authorNelson, Aaron
dc.contributor.authorPrice, Dana
dc.contributor.authorDapul, Heda
dc.contributor.authorSantos, Laura
dc.contributor.authorKahoud, Robert
dc.contributor.authorFrancoeur, Conall
dc.contributor.authorAppavu, Brian
dc.contributor.authorGuilliams, Kristin P.
dc.contributor.authorAgner, Shannon C.
dc.contributor.authorWalson, Karen H.
dc.contributor.authorRasmussen, Lindsey
dc.contributor.authorJanas, Anna
dc.contributor.authorFerrazzano, Peter
dc.contributor.authorFarias-Moeller, Raquel
dc.contributor.authorSnooks, Kellie C.
dc.contributor.authorChang, Chung Chou H.
dc.contributor.authorYun, James
dc.contributor.authorSchober, Michelle E.
dc.date.accessioned2022-01-20T12:51:33Z
dc.date.available2022-01-20T12:51:33Z
dc.date.issued2022-03-01
dc.identifier.urihttp://hdl.handle.net/10713/17693
dc.description.abstractBackground: Our objective was to characterize the frequency, early impact, and risk factors for neurological manifestations in hospitalized children with acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or multisystem inflammatory syndrome in children (MIS-C). Methods: Multicenter, cross-sectional study of neurological manifestations in children aged <18 years hospitalized with positive SARS-CoV-2 test or clinical diagnosis of a SARS-CoV-2-related condition between January 2020 and April 2021. Multivariable logistic regression to identify risk factors for neurological manifestations was performed. Results: Of 1493 children, 1278 (86%) were diagnosed with acute SARS-CoV-2 and 215 (14%) with MIS-C. Overall, 44% of the cohort (40% acute SARS-CoV-2 and 66% MIS-C) had at least one neurological manifestation. The most common neurological findings in children with acute SARS-CoV-2 and MIS-C diagnosis were headache (16% and 47%) and acute encephalopathy (15% and 22%), both P < 0.05. Children with neurological manifestations were more likely to require intensive care unit (ICU) care (51% vs 22%), P < 0.001. In multivariable logistic regression, children with neurological manifestations were older (odds ratio [OR] 1.1 and 95% confidence interval [CI] 1.07 to 1.13) and more likely to have MIS-C versus acute SARS-CoV-2 (OR 2.16, 95% CI 1.45 to 3.24), pre-existing neurological and metabolic conditions (OR 3.48, 95% CI 2.37 to 5.15; and OR 1.65, 95% CI 1.04 to 2.66, respectively), and pharyngeal (OR 1.74, 95% CI 1.16 to 2.64) or abdominal pain (OR 1.43, 95% CI 1.03 to 2.00); all P < 0.05. Conclusions: In this multicenter study, 44% of children hospitalized with SARS-CoV-2-related conditions experienced neurological manifestations, which were associated with ICU admission and pre-existing neurological condition. Posthospital assessment for, and support of, functional impairment and neuroprotective strategies are vitally needed.en_US
dc.description.sponsorshipOhio State Universityen_US
dc.description.urihttps://doi.org/10.1016/j.pediatrneurol.2021.12.010en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPediatric Neurologyen_US
dc.subjectChild developmenten_US
dc.subjectNeurological manifestationsen_US
dc.subjectPediatricsen_US
dc.subjectSARS-CoV-2en_US
dc.titlePrevalence and Risk Factors of Neurologic Manifestations in Hospitalized Children Diagnosed with Acute SARS-CoV-2 or MIS-Cen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.pediatrneurol.2021.12.010
dc.source.journaltitlePediatric Neurology
dc.source.volume128
dc.source.beginpage33
dc.source.endpage44


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