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dc.contributor.authorBateman, Nicholas W.
dc.contributor.authorTarney, Christopher M.
dc.contributor.authorAbulez, Tamara S.
dc.contributor.authorHood, Brian L.
dc.contributor.authorConrads, Kelly A.
dc.contributor.authorZhou, Ming
dc.contributor.authorSoltis, Anthony R.
dc.contributor.authorTeng, Pang Ning
dc.contributor.authorJackson, Amanda
dc.contributor.authorTian, Chunqiao
dc.contributor.authorDalgard, Clifton L.
dc.contributor.authorWilkerson, Matthew D.
dc.contributor.authorKessler, Michael D.
dc.contributor.authorGoecker, Zachary
dc.contributor.authorLoffredo, Jeremy
dc.contributor.authorShriver, Craig D.
dc.contributor.authorHu, Hai
dc.contributor.authorCote, Michele
dc.contributor.authorParker, Glendon J.
dc.contributor.authorSegars, James
dc.contributor.authorAl-Hendy, Ayman
dc.contributor.authorRisinger, John I.
dc.contributor.authorPhippen, Neil T.
dc.contributor.authorCasablanca, Yovanni
dc.contributor.authorDarcy, Kathleen M.
dc.contributor.authorMaxwell, G. Larry
dc.contributor.authorConrads, Thomas P.
dc.contributor.authorO'Connor, Timothy D.
dc.date.accessioned2022-01-19T17:14:47Z
dc.date.available2022-01-19T17:14:47Z
dc.date.issued2022-01-21
dc.identifier.urihttp://hdl.handle.net/10713/17646
dc.description.abstractCharacterization of ancestry-linked peptide variants in disease-relevant patient tissues represents a foundational step to connect patient ancestry with disease pathogenesis. Nonsynonymous single-nucleotide polymorphisms encoding missense substitutions within tryptic peptides exhibiting high allele frequencies in European, African, and East Asian populations, termed peptide ancestry informative markers (pAIMs), were prioritized from 1000 genomes. In silico analysis identified that as few as 20 pAIMs can determine ancestry proportions similarly to >260K SNPs (R2 = 0.99). Multiplexed proteomic analysis of >100 human endometrial cancer cell lines and uterine leiomyoma tissues combined resulted in the quantitation of 62 pAIMs that correlate with patient race and genotype-confirmed ancestry. Candidates include a D451E substitution in GC vitamin D-binding protein previously associated with altered vitamin D levels in African and European populations. pAIMs will support generalized proteoancestry assessment as well as efforts investigating the impact of ancestry on the human proteome and how this relates to the pathogenesis of uterine neoplasms. © 2021 The Author(s)en_US
dc.description.sponsorshipU.S. Department of Defenseen_US
dc.description.urihttps://doi.org/10.1016/j.isci.2021.103665en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofiScienceen_US
dc.subjectGenomicsen_US
dc.subjectPrecision medicineen_US
dc.subjectProteogenomicsen_US
dc.subjectProteomicsen_US
dc.titlePeptide ancestry informative markers in uterine neoplasms from women of European, African, and Asian ancestryen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.isci.2021.103665
dc.source.journaltitleiScience
dc.source.volume25
dc.source.issue1


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