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dc.contributor.authorStanislawski, Maggie A
dc.contributor.authorStamper, Christopher E
dc.contributor.authorStearns-Yoder, Kelly A
dc.contributor.authorHoisington, Andrew J
dc.contributor.authorBrostow, Diana P
dc.contributor.authorForster, Jeri E
dc.contributor.authorPostolache, Teodor T
dc.contributor.authorLowry, Christopher A
dc.contributor.authorBrenner, Lisa A
dc.date.accessioned2022-01-19T16:41:35Z
dc.date.available2022-01-19T16:41:35Z
dc.date.issued2021-09-14
dc.identifier.urihttp://hdl.handle.net/10713/17634
dc.description.abstractThe gut microbiome is impacted by environmental exposures and has been implicated in many physical and mental health conditions, including anxiety disorders, affective disorders, and trauma- and stressor-related disorders such as posttraumatic stress disorder (PTSD). United States (US) military Veterans are a unique population in that their military-related exposures can have consequences for both physical and mental health, but the gut microbiome of this population has been understudied. In this publication, we describe exposures, health conditions, and medication use of Veterans in the US Veteran Microbiome Project (US-VMP) and examine the associations between these characteristics and the gut microbiota. This cohort included 331 US Veterans seeking healthcare with the Veterans Health Administration who were 83% male with an average (±SD) age of 47.6 ​± ​13.4 years. The cohort displayed a high prevalence of PTSD (49.8%) and history of traumatic brain injuries (76.1%), and high current use of prescription medications (74.9%) to treat various acute and chronic conditions. We observed significant associations between the gut microbiota composition and gastroenteritis, peripheral vascular disease (PVD), bipolar disorders, symptoms of severe depression based on the Beck Depression Inventory, stimulant and opioid use disorders, beta-blockers, serotonin and norepinephrine reuptake inhibitor antidepressants, diabetes medications, and proton pump inhibitors. Many of the Veteran characteristics examined were associated with altered relative abundances of specific taxa. We found that PVD and cardiovascular disease were associated with lower microbiota diversity in the gut (i.e., α-diversity), while supplemental vitamin use was associated with higher α-diversity. Our study contributes novel insights as to whether the unique exposures of Veterans in this cohort correlate with gut microbiota characteristics and, in line with previous findings with other population-level studies of the microbiome, confirms associations between numerous health conditions and medications with the gut microbiome.en_US
dc.description.urihttps://doi.org/10.1016/j.bbih.2021.100346en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBrain, Behavior, & Immunity - Healthen_US
dc.rights© 2021 The Authors.en_US
dc.subjectBipolar disorderen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectDepressionen_US
dc.subjectGut microbiomeen_US
dc.subjectMedicationsen_US
dc.subjectMicrobiomeen_US
dc.subjectProton pump inhibitorsen_US
dc.subjectVeteranen_US
dc.titleCharacterization of the gut microbiota among Veterans with unique military-related exposures and high prevalence of chronic health conditions: A United States-Veteran Microbiome Project (US-VMP) study.en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bbih.2021.100346
dc.identifier.pmid34988495
dc.source.journaltitleBrain, behavior, & immunity - health
dc.source.volume18
dc.source.beginpage100346
dc.source.endpage
dc.source.countryUnited States


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