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    Pediatric Chemotherapy Drugs Associated With Cardiotoxicity.

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    Author
    Hitawala, Gazala
    Jain, Esha
    Castellanos, Lisett
    Garimella, Radhika
    Akku, Radhika
    Chamavaliyathil, Adila K
    Irfan, Huma
    Jaiswal, Vikash
    Quinonez, Jonathan
    Dakroub, Maher
    Hanif, Muhammad
    Baloch, Ali H
    Gomez, Ivan S
    Dylewski, John
    Show allShow less

    Date
    2021-11-17
    Journal
    Cureus
    Publisher
    Cureus, Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.7759/cureus.19658
    Abstract
    Pediatric cancers are a common cause of childhood morbidity. As a result, chemotherapeutic regimens have been designed to target childhood cancers. These medications are necessary to treat pediatric cancers, however, oncology management options are accompanied by multiple negative and potentially fatal adverse effects. Although anthracyclines are the most commonly used chemotherapeutic agents associated with cardiotoxicity, we also explore other chemotherapeutic drugs used in children that can potentially affect the heart. Genetic variations resulting in single nucleotide polymorphism (SNP) have the propensity to modify the cardiotoxic effects of the chemotherapy drugs. The clinical presentation of the cardiac effects can vary from arrhythmias and heart failure to completely asymptomatic. A range of imaging studies and laboratory investigations can protect the heart from severe outcomes. The physiology of the heart and the effect of drugs in children vary vividly from adults; therefore, it is crucial to study the cardiotoxic effect of chemotherapy drugs in the pediatric population. This review highlights the potential contributing factors for cardiotoxicity in the pediatric population and discusses the identification and management options.
    Rights/Terms
    Copyright © 2021, Hitawala et al.
    Keyword
    anthracycline
    cardiotoxic agents
    chemotherapy associated cardiotoxicity
    dexrazoxane
    pediatric cancer
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17625
    ae974a485f413a2113503eed53cd6c53
    10.7759/cureus.19658
    Scopus Count
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