Booster of mRNA-1273 Vaccine Reduces SARS-CoV-2 Omicron Escape from Neutralizing Antibodies.
AuthorDoria-Rose, Nicole A
Schmidt, Stephen D
Atmar, Robert L
Lyke, Kirsten E
Gaudinski, Martin R
Black, Walker P
Ledgerwood, Julie E
Misasi, John N
Roberts, Paul C
Mascola, John R
Montefiori, David C
JournalmedRxiv : the Preprint Server for Health Sciences
PublisherCold Spring Harbor Laboratory
MetadataShow full item record
AbstractThe Omicron variant of SARS-CoV-2 is raising concerns because of its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the potential risk of this variant to existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested for neutralizing activity against Omicron and compared to neutralization titers against D614G and Beta in live virus and pseudovirus assays. Omicron was 41-84-fold less sensitive to neutralization than D614G and 5.3-7.4-fold less sensitive than Beta when assayed with serum samples obtained 4 weeks after 2 standard inoculations with 100 µg mRNA-1273. A 50 µg boost increased Omicron neutralization titers and may substantially reduce the risk of symptomatic vaccine breakthrough infections.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/17595
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