Epigenetic marker of telomeric age is associated with exacerbations and hospitalizations in chronic obstructive pulmonary disease.
Author
Hernández Cordero, Ana IYang, Chen Xi
Li, Xuan
Milne, Stephen
Chen, Virginia
Hollander, Zsuzsanna
Ng, Raymond
Criner, Gerard J
Woodruff, Prescott G
Lazarus, Stephen C
Connett, John E
Han, MeiLan K
Martinez, Fernando J
Reed, Robert M
Man, S F Paul
Leung, Janice M
Sin, Don D
Date
2021-12-22Journal
Respiratory ResearchPublisher
Springer NatureType
Article
Metadata
Show full item recordAbstract
Participants with short DNAmTL demonstrated increased risk of exacerbation (P = 0.02) and hospitalization (P = 0.03) compared to those with longer DNAmTL. DNAmTL age acceleration was associated with higher rates of exacerbation (P = 1.35 × 10-04) and hospitalization (P = 5.21 × 10-03) and poor health status (lower SGRQ scores) independent of chronological age (P = 0.03).Rights/Terms
© 2021. The Author(s).Identifier to cite or link to this item
http://hdl.handle.net/10713/17579ae974a485f413a2113503eed53cd6c53
10.1186/s12931-021-01911-9
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