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dc.contributor.authorAmanat, Fatima
dc.contributor.authorStrohmeier, Shirin
dc.contributor.authorMeade, Philip
dc.contributor.authorDambrauskas, Nicholas
dc.contributor.authorMühlemann, Barbara
dc.contributor.authorSmith, Derek J
dc.contributor.authorVigdorovich, Vladimir
dc.contributor.authorSather, D Noah
dc.contributor.authorCoughlan, Lynda
dc.contributor.authorKrammer, Florian
dc.date.accessioned2022-01-19T14:25:24Z
dc.date.available2022-01-19T14:25:24Z
dc.date.issued2021-12-16
dc.identifier.urihttp://hdl.handle.net/10713/17568
dc.descriptionFrom publisher: This is an uncorrected proof.en_US
dc.description.abstractVaccines against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have been highly efficient in protecting against Coronavirus Disease 2019 (COVID-19). However, the emergence of viral variants that are more transmissible and, in some cases, escape from neutralizing antibody responses has raised concerns. Here, we evaluated recombinant protein spike antigens derived from wild-type SARS-CoV-2 and from variants B.1.1.7, B.1.351, and P.1 for their immunogenicity and protective effect in vivo against challenge with wild-type SARS-CoV-2 in the mouse model. All proteins induced high neutralizing antibodies against the respective viruses but also induced high cross-neutralizing antibody responses. The decline in neutralizing titers between variants was moderate, with B.1.1.7-vaccinated animals having a maximum fold reduction of 4.8 against B.1.351 virus. P.1 induced the most cross-reactive antibody responses but was also the least immunogenic in terms of homologous neutralization titers. However, all antigens protected from challenge with wild-type SARS-CoV-2 in a mouse model.en_US
dc.description.urihttps://doi.org/10.1371/journal.pbio.3001384en_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS Biologyen_US
dc.titleVaccination with SARS-CoV-2 variants of concern protects mice from challenge with wild-type virus.en_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pbio.3001384
dc.identifier.pmid34914685
dc.source.journaltitlePLoS biology
dc.source.volume19
dc.source.issue12
dc.source.beginpagee3001384
dc.source.endpage
dc.source.countryUnited States


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