• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Levels of prolactin and testosterone and associated sexual dysfunction and breast abnormalities in men with schizophrenia treated with antipsychotic medications.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Author
    Redman, Brianne
    Kitchen, Chris
    Johnson, Kirk W
    Bezwada, Padma
    Kelly, Deanna L
    Date
    2021-08-18
    Journal
    Journal of Psychiatric Research
    Publisher
    Elsevier Ltd.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1016/j.jpsychires.2021.08.022
    Abstract
    Sexual dysfunction is one of the most bothersome adverse drug effects seen in men and women taking antipsychotic medications and negatively impacts medication adherence. Antipsychotic medications are associated with hyperprolactinemia, which is known to contribute to sexual and hormonal side effects in men. However, testosterone also plays a key factor in male sexual function and may be affected by abnormal prolactin levels through gonadotropin-releasing hormone inhibition. This study was a pilot study undertaken to assess the prevalence of elevations in prolactin levels, related reductions in testosterone levels, associated symptoms of sexual dysfunction and breast abnormalities in male participants, and related distress to these symptoms in men taking prolactin-elevating antipsychotic medications. The study was conducted as a cross-sectional study. Our results showed a notably high prevalence of sexual side effects in this population, with gynecomastia occurring in 50% and penile-related symptoms in 73%. Additionally, we found elevated prolactin levels in 68% and low testosterone levels in 55% of our participants. This study was limited in its power due to a small sample size of 22 men and the lack of a control group. Still, even in our relatively small sample, we see a trend of hyperprolactinemia being associated with low testosterone and a significant correlation of low testosterone levels with penile-related symptoms. This suggests that testosterone plays a major role in the sexual side effects reported by men taking antipsychotics, although larger studies are needed to further categorize this relationship.
    Rights/Terms
    Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
    Keyword
    Antipsychotic
    Gynecomastia
    Hyperprolactinemia
    Sexual dysfunction
    Testosterone
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17567
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jpsychires.2021.08.022
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Sexual dysfunction in men treated with depot antipsychotic drugs: a pilot study.
    • Authors: Plevin D, Galletly C, Roughan P
    • Issue date: 2007 Dec
    • Prolactin and Thyroid Stimulating Hormone (TSH) Levels and Sexual Dysfunction in Patients with Schizophrenia Treated with Conventional Antipsychotic Medication: A Cross-Sectional Study.
    • Authors: Zhang Y, Tang Z, Ruan Y, Huang C, Wu J, Lu Z, Li W, Tang Y, Liu J, She J, Wang TT, Zhu Y, Teng ZW, Zeng Y
    • Issue date: 2018 Dec 16
    • Improvement in hyperprolactinemia and reproductive comorbidities in patients with schizophrenia switched from conventional antipsychotics or risperidone to olanzapine.
    • Authors: Kinon BJ, Ahl J, Liu-Seifert H, Maguire GA
    • Issue date: 2006 Jun
    • Bone loss associated with hyperprolactinemia in patients with schizophrenia.
    • Authors: Kinon BJ, Liu-Seifert H, Stauffer VL, Jacob J
    • Issue date: 2013 Oct
    • Prevalence of hyperprolactinemia in schizophrenic patients treated with conventional antipsychotic medications or risperidone.
    • Authors: Kinon BJ, Gilmore JA, Liu H, Halbreich UM
    • Issue date: 2003 Apr
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.