Body Composition and Incident Heart Failure in Older Adults: Results From 2 Prospective Cohorts.
Author
Zhang, LiliBartz, Traci M
Santanasto, Adam
Djoussé, Luc
Mukamal, Kenneth J
Forman, Daniel E
Hirsch, Calvin H
Newman, Anne B
Gottdiener, John S
Kizer, Jorge R
Date
2021-12-20Journal
Journal of the American Heart AssociationPublisher
Wiley-BlackwellType
Article
Metadata
Show full item recordAbstract
Background Aging is associated with central fat redistribution and skeletal muscle decline, yet the relationships of tissue compartments with heart failure (HF) remain incompletely characterized. We assessed the contribution of body composition to incident HF in elders. Methods and Results Participants from 2 older cohorts who completed dual-energy X-ray absorptiometry (DEXA) and, in one cohort, computed tomography were included. We evaluated associations with incident HF for DEXA principal components (PCs) and total lean, appendicular lean, total fat and trunk fat mass; and for computed tomography measures of abdominal visceral and subcutaneous fat, thigh muscle, intermuscular fat area and thigh muscle density. DEXA analysis included 3621, and computed tomography analysis 2332 participants. During median follow-up of 11.8 years, 927 participants developed HF. DEXA principal components showed no relationship with HF. After adjustment for height, weight, and cardiovascular risk factors, total lean mass was near significantly associated with higher HF (hazard ratio [HR], 1.25 per SD [1.00-1.56]), whereas total fat mass and thigh muscle density were significantly related to lower HF (HR, 0.82 [0.68-0.99] and HR, 0.87 [0.78-0.97], respectively). Patterns were similar for HF subtypes. The relationships with HF for total lean and fat mass were attenuated after adjusting for intercurrent atrial fibrillation or excluding high natriuretic peptide levels. Conclusions Total lean mass was positively associated, while total fat mass and thigh muscle density were inversely associated, with incident HF. These findings highlight the limitations of DEXA for assessment of HF risk in elders and support the preeminence of computed tomography-measured skeletal muscle quality over mass as a determinant of HF incidence.Identifier to cite or link to this item
http://hdl.handle.net/10713/17561ae974a485f413a2113503eed53cd6c53
10.1161/JAHA.121.023707
Scopus Count
Collections
Related articles
- Association Between Thigh Muscle Fat Infiltration and Incident Heart Failure: The Health ABC Study.
- Authors: Huynh K, Ayers C, Butler J, Neeland I, Kritchevsky S, Pandey A, Barton G, Berry JD
- Issue date: 2022 Jul
- Impact of Incident Heart Failure on Body Composition Over Time in the Health, Aging, and Body Composition Study Population.
- Authors: Forman DE, Santanasto AJ, Boudreau R, Harris T, Kanaya AM, Satterfield S, Simonsick EM, Butler J, Kizer JR, Newman AB
- Issue date: 2017 Sep
- Visceral adiposity and inflammatory bowel disease.
- Authors: Rowan CR, McManus J, Boland K, O'Toole A
- Issue date: 2021 Nov
- Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat.
- Authors: Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE
- Issue date: 1997 Oct
- Age-related changes in fat deposition in mid-thigh muscle in women: relationships with metabolic cardiovascular disease risk factors.
- Authors: Ryan AS, Nicklas BJ
- Issue date: 1999 Feb