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    Respiratory Syncytial Virus (RSV) Neutralizing Antibodies at Birth Predict Protection from RSV Illness in Infants in the First 3 Months of Life.

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    Author
    Buchwald, Andrea G
    Graham, Barney S
    Traore, Awa
    Haidara, Fadima Cheick
    Chen, Man
    Morabito, Kaitlyn
    Lin, Bob C
    Sow, Samba O
    Levine, Myron M
    Pasetti, Marcela F
    Tapia, Milagritos D
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    Date
    2021-12-06
    Journal
    Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32463443/
    https://doi.org/10.1093/cid/ciaa648
    Abstract
    BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of viral pneumonia and bronchiolitis during the first 6 months of life. Placentally transferred antibodies can prevent severe RSV illness, and maternal immunization may reduce illness in young infants. Identification of protective antibody levels facilitates the advancement of vaccine candidates and maternal immunization. METHODS: We conducted a nested case-control study with 587 Malian mother-infant pairs, followed from birth to age 6 months. RSV cases were infants who developed influenza-like illness (ILI) or pneumonia and were RSV-positive by polymerase chain reaction. Cases were matched to healthy controls and RSV-negative ILI controls. RSV-A and RSV-B neutralizing antibodies were measured in maternal, cord blood, and infant sera at age 3 and 6 months. RESULTS: Maternal antibodies were efficiently transferred to infants. Maternal and infant RSV titers were strongly correlated. Infant antibody titers against RSV-A were 3 times higher than those against RSV-B. At birth, infants who remained healthy had significantly higher RSV-A and RSV-B titers compared with infants who subsequently contracted RSV. RSV-A inhibitory concentration (IC)80 titer >239 or RSV-B titer >60 at birth was significantly associated with being a healthy control compared with an RSV case within the first 3 months of life. RSV-A IC80 titers in cord blood were associated with decreased episodes of pneumonia. CONCLUSIONS: Maternally acquired RSV antibodies were associated with protection of infants against community-detected cases of RSV-ILI and pneumonia. RSV titers in cord blood can predict whether an infant will be infected with RSV or remain uninfected.
    Rights/Terms
    © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.
    Keyword
    maternal antibodies
    protective threshold
    respiratory syncytial virus
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17525
    ae974a485f413a2113503eed53cd6c53
    10.1093/cid/ciaa648
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