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dc.contributor.authorGoodman, Katherine E
dc.contributor.authorMagder, Laurence S
dc.contributor.authorBaghdadi, Jonathan D
dc.contributor.authorPineles, Lisa
dc.contributor.authorLevine, Andrea R
dc.contributor.authorPerencevich, Eli N
dc.contributor.authorHarris, Anthony D
dc.date.accessioned2022-01-18T21:23:46Z
dc.date.available2022-01-18T21:23:46Z
dc.date.issued2021-12-06
dc.identifier.urihttp://hdl.handle.net/10713/17522
dc.description.abstractBACKGROUND: The relationship between common patient characteristics, such as sex and metabolic comorbidities, and mortality from coronavirus disease 2019 (COVID-19) remains incompletely understood. Emerging evidence suggests that metabolic risk factors may also vary by age. This study aimed to determine the association between common patient characteristics and mortality across age-groups among COVID-19 inpatients. METHODS: We performed a retrospective cohort study of patients discharged from hospitals in the Premier Healthcare Database between April-June 2020. Inpatients were identified using COVID-19 ICD-10-CM diagnosis codes. A priori-defined exposures were sex and present-on-admission hypertension, diabetes, obesity, and interactions between age and these comorbidities. Controlling for additional confounders, we evaluated relationships between these variables and in-hospital mortality in a log-binomial model. RESULTS: Among 66 646 (6.5%) admissions with a COVID-19 diagnosis, across 613 U.S. hospitals, 12 388 (18.6%) died in-hospital. In multivariable analysis, male sex was independently associated with 30% higher mortality risk (aRR, 1.30, 95% CI: 1.26-1.34). Diabetes without chronic complications was not a risk factor at any age (aRR 1.01, 95% CI: 0.96-1.06), and hypertension without chronic complications was a risk factor only in 20-39 year-olds (aRR, 1.68, 95% CI: 1.17-2.40). Diabetes with chronic complications, hypertension with chronic complications, and obesity were risk factors in most age-groups, with highest relative risks among 20-39 year-olds (respective aRRs 1.79, 2.33, 1.92; P-values ≤ .002). CONCLUSIONS: Hospitalized men with COVID-19 are at increased risk of death across all ages. Hypertension, diabetes with chronic complications, and obesity demonstrated age-dependent effects, with the highest relative risks among adults aged 20-39.en_US
dc.description.urihttps://doi.org/10.1093/cid/ciaa1787en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/33337474/en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofClinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of Americaen_US
dc.rights© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.en_US
dc.subjectCOVID-19en_US
dc.subjectclaims dataen_US
dc.subjecthypertensionen_US
dc.subjectmetabolic comorbiditiesen_US
dc.subjectsexen_US
dc.titleImpact of Sex and Metabolic Comorbidities on Coronavirus Disease 2019 (COVID-19) Mortality Risk Across Age Groups: 66 646 Inpatients Across 613 U.S. Hospitals.en_US
dc.typeArticleen_US
dc.identifier.doi10.1093/cid/ciaa1787
dc.identifier.pmid33337474
dc.source.journaltitleClinical infectious diseases : an official publication of the Infectious Diseases Society of America
dc.source.volume73
dc.source.issue11
dc.source.beginpagee4113
dc.source.endpagee4123
dc.source.countryUnited States


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