Schizophrenia Patients Show Largely Similar Salience Signaling Compared to Healthy Controls in an Observational Task Environment
AuthorCulbreth, Adam J
Ross, Thomas J
Salmeron, Betty J
Gold, James M
Stein, Elliot A
Waltz, James A
MetadataShow full item record
AbstractRecent evidence suggests that the aberrant signaling of salience is associated with psychotic illness. Salience, however, can take many forms in task environments. For example, salience may refer to any of the following: (1) the valence of an outcome, (2) outcomes that are unexpected, called reward prediction errors (PEs), or (3) cues associated with uncertain outcomes. Here, we measure brain responses to different forms of salience in the context of a passive PE-signaling task, testing whether patients with schizophrenia (SZ) showed aberrant signaling of particular types of salience. We acquired event-related MRI data from 29 SZ patients and 23 controls during the performance of a passive outcome prediction task. Across groups, we found that the anterior insula and posterior parietal cortices were activated to multiple different types of salience, including PE magnitude and heightened levels of uncertainty. However, BOLD activation to salient events was not significantly different between patients and controls in many regions, including the insula, posterior parietal cortices, and default mode network nodes. Such results suggest that deficiencies in salience processing in SZ may not result from an impaired ability to signal salience per se, but instead the ability to use such signals to guide future actions. Notably, no between-group differences were observed in BOLD signal changes associated with PE-signaling in the striatum. However, positive symptom severity was found to significantly correlate with the magnitudes of salience contrasts in default mode network nodes. Our results suggest that, in an observational environment, SZ patients may show an intact ability to activate striatal and cortical regions to rewarding and non-rewarding salient events. Furthermore, reduced deactivation of a hypothesized default mode network node for SZ participants with high levels of positive symptoms, following salient events, point to abnormalities in interactions of the salience network with other brain networks, and their potential importance to positive symptoms.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/17467
- Aberrant dependence of default mode/central executive network interactions on anterior insular salience network activity in schizophrenia.
- Authors: Manoliu A, Riedl V, Zherdin A, Mühlau M, Schwerthöffer D, Scherr M, Peters H, Zimmer C, Förstl H, Bäuml J, Wohlschläger AM, Sorg C
- Issue date: 2014 Mar
- Expected value and prediction error abnormalities in depression and schizophrenia.
- Authors: Gradin VB, Kumar P, Waiter G, Ahearn T, Stickle C, Milders M, Reid I, Hall J, Steele JD
- Issue date: 2011 Jun
- The roles of reward, default, and executive control networks in set-shifting impairments in schizophrenia.
- Authors: Waltz JA, Kasanova Z, Ross TJ, Salmeron BJ, McMahon RP, Gold JM, Stein EA
- Issue date: 2013
- Salience network-midbrain dysconnectivity and blunted reward signals in schizophrenia.
- Authors: Gradin VB, Waiter G, O'Connor A, Romaniuk L, Stickle C, Matthews K, Hall J, Douglas Steele J
- Issue date: 2013 Feb 28
- Neural correlates of reward processing in healthy siblings of patients with schizophrenia.
- Authors: Hanssen E, van der Velde J, Gromann PM, Shergill SS, de Haan L, Bruggeman R, Krabbendam L, Aleman A, van Atteveldt N
- Issue date: 2015