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    Heavy ion minibeam therapy: Side effects in normal brain

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    Author
    Eley, John G.
    Haga, Catherine W.
    Keller, Asaf
    Lazenby, Ellis M.
    Raver, Charles
    Rusek, Adam
    Dilmanian, Farrokh Avraham
    Krishnan, Sunil
    Waddell, Jaylyn
    Date
    2021-12-09
    Journal
    Cancers
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/cancers13246207
    Abstract
    The purpose of this work was to investigate whether minibeam therapy with heavy ions might offer improvements of the therapeutic ratio for the treatment of human brain cancers. To assess neurotoxicity, we irradiated normal juvenile rats using 120 MeV lithium‐7 ions at an absorbed integral dose of 20 Gy. Beams were configured either as a solid parallel circular beam or as an array of planar parallel minibeams having 300‐micron width and 1‐mm center‐to‐center spacing within a circular array. We followed animals for 6 months after treatment and utilized behavioral testing and immunohistochemical studies to investigate the resulting cognitive impairment and chronic pathologic changes. We found both solid‐beam therapy and minibeam therapy to result in cognitive impairment compared with sham controls, with no apparent reduction in neurotoxicity using heavy ion minibeams instead of solid beams under the conditions of this study. © 2021 by the authors.
    Sponsors
    National Institutes of Health
    Keyword
    Brain
    Brain cancer
    CNS
    Cognitive
    Microbeam
    Particle therapy
    Pediatric
    Rat
    Rodent
    Toxicity
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17446
    ae974a485f413a2113503eed53cd6c53
    10.3390/cancers13246207
    Scopus Count
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