Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review
Date
2021-11-25Journal
Frontiers in ImmunologyPublisher
Frontiers Media S.A.Type
Article
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Show full item recordAbstract
Although breast cancer has been previously considered "cold" tumors, numerous studies are currently conducted to explore the great potentials of immunotherapies in improving breast cancer patient outcomes. In addition to the focus on stimulating adaptive immunity for antitumor responses, growing evidence showed the importance of triggering host innate immunity to eradicate established tumors and/or control tumor metastasis of breast cancer. In this review, we first briefly introduce the breast tumor immune microenvironment. We also discuss innate immune targets and pathways and mechanisms of their synergy with the adaptive antitumor response and other treatment strategies. Lastly, we review clinical trials targeting innate immune pathways for breast cancer therapies.Rights/Terms
Copyright © 2021 Ye, Xu, Chen, Liu and Cheng.Identifier to cite or link to this item
http://hdl.handle.net/10713/17427ae974a485f413a2113503eed53cd6c53
10.3389/fimmu.2021.771201
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