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    Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review

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    Author
    Ye, Yanqi
    Xu, Chun
    Chen, Fengqian
    Liu, Qi
    Cheng, Ning
    Date
    2021-11-25
    Journal
    Frontiers in Immunology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fimmu.2021.771201
    Abstract
    Although breast cancer has been previously considered "cold" tumors, numerous studies are currently conducted to explore the great potentials of immunotherapies in improving breast cancer patient outcomes. In addition to the focus on stimulating adaptive immunity for antitumor responses, growing evidence showed the importance of triggering host innate immunity to eradicate established tumors and/or control tumor metastasis of breast cancer. In this review, we first briefly introduce the breast tumor immune microenvironment. We also discuss innate immune targets and pathways and mechanisms of their synergy with the adaptive antitumor response and other treatment strategies. Lastly, we review clinical trials targeting innate immune pathways for breast cancer therapies.
    Rights/Terms
    Copyright © 2021 Ye, Xu, Chen, Liu and Cheng.
    Keyword
    breast cancer
    cancer immunotherapy
    clinical studies
    innate immunity
    vaccine adjuvants
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17427
    ae974a485f413a2113503eed53cd6c53
    10.3389/fimmu.2021.771201
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