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    Implementation and Accuracy of BinaxNOW Rapid Antigen COVID-19 Test in Asymptomatic and Symptomatic Populations in a High-Volume Self-Referred Testing Site

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    Author
    Siddiqui, Zishan K
    Chaudhary, Mihir
    Robinson, Matthew L
    McCall, Anna B
    Peralta, Ria
    Esteve, Rogette
    Callahan, Charles W
    Manabe, Yukari C
    Campbell, James D
    Johnson, J Kristie
    Elhabashy, Maryam
    Kantsiper, Melinda
    Ficke, James R
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    Date
    2021-12-01
    Journal
    Microbiology Spectrum
    Publisher
    American Society for Microbiology
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1128/Spectrum.01008-21
    Abstract
    Rapid antigen tests are simple to perform and provide results within 15 min. We describe our implementation and assess performance of the BinaxNOW COVID-19 Antigen Test (Abbott Laboratories) in 6,099 adults at a self-referred walk-up testing site. Participants were grouped by self-reported COVID-19 exposure and symptom status. Most (89%) were asymptomatic, of whom 17% reported potential exposure. Overall test sensitivity compared with reference laboratory reverse-transcription [RT] PCR testing was 81% (95% confidence interval [CI] 75%, 86%). It was higher in symptomatic (87%; 95% CI 80%, 91%) than asymptomatic (71%; 95% CI 61%, 80%) individuals. Sensitivity was 82% (95% CI 66%, 91%) for asymptomatic individuals with potential exposure and 64% (95% CI 51%, 76%) for those with no exposure. Specificity was greater than 99% for all groups. BinaxNOW has high accuracy among symptomatic individuals and is below the FDA threshold for emergency use authorization in asymptomatic individuals. Nonetheless, rapid antigen testing quickly identifies positive among those with symptoms and/or close contact exposure and could expedite isolation and treatment. IMPORTANCE The BinaxNOW rapid antigen COVID-19 test had a sensitivity of 87% in symptomatic and 71% asymptomatic individuals when performed by health care workers in a high-throughput setting. The performance may expedite isolation decisions or referrals for time-sensitive monoclonal antibody treatment in communities where timely COVID PCR tests are unavailable.
    Keyword
    COVID-19
    SARS-CoV-2
    field hospital
    point-of-care testing
    rapid antigen testing
    reverse transcription PCR
    sensitivity and specificity
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17340
    ae974a485f413a2113503eed53cd6c53
    10.1128/Spectrum.01008-21
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles

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