Implementation and Accuracy of BinaxNOW Rapid Antigen COVID-19 Test in Asymptomatic and Symptomatic Populations in a High-Volume Self-Referred Testing Site
Author
Siddiqui, Zishan KChaudhary, Mihir
Robinson, Matthew L
McCall, Anna B
Peralta, Ria
Esteve, Rogette
Callahan, Charles W
Manabe, Yukari C
Campbell, James D
Johnson, J Kristie
Elhabashy, Maryam
Kantsiper, Melinda
Ficke, James R
Date
2021-12-01Journal
Microbiology SpectrumPublisher
American Society for MicrobiologyType
Article
Metadata
Show full item recordAbstract
Rapid antigen tests are simple to perform and provide results within 15 min. We describe our implementation and assess performance of the BinaxNOW COVID-19 Antigen Test (Abbott Laboratories) in 6,099 adults at a self-referred walk-up testing site. Participants were grouped by self-reported COVID-19 exposure and symptom status. Most (89%) were asymptomatic, of whom 17% reported potential exposure. Overall test sensitivity compared with reference laboratory reverse-transcription [RT] PCR testing was 81% (95% confidence interval [CI] 75%, 86%). It was higher in symptomatic (87%; 95% CI 80%, 91%) than asymptomatic (71%; 95% CI 61%, 80%) individuals. Sensitivity was 82% (95% CI 66%, 91%) for asymptomatic individuals with potential exposure and 64% (95% CI 51%, 76%) for those with no exposure. Specificity was greater than 99% for all groups. BinaxNOW has high accuracy among symptomatic individuals and is below the FDA threshold for emergency use authorization in asymptomatic individuals. Nonetheless, rapid antigen testing quickly identifies positive among those with symptoms and/or close contact exposure and could expedite isolation and treatment. IMPORTANCE The BinaxNOW rapid antigen COVID-19 test had a sensitivity of 87% in symptomatic and 71% asymptomatic individuals when performed by health care workers in a high-throughput setting. The performance may expedite isolation decisions or referrals for time-sensitive monoclonal antibody treatment in communities where timely COVID PCR tests are unavailable.Keyword
COVID-19SARS-CoV-2
field hospital
point-of-care testing
rapid antigen testing
reverse transcription PCR
sensitivity and specificity
Identifier to cite or link to this item
http://hdl.handle.net/10713/17340ae974a485f413a2113503eed53cd6c53
10.1128/Spectrum.01008-21
Scopus Count
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