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dc.contributor.authorCoker, Modupe O
dc.contributor.authorAkhigbe, Paul
dc.contributor.authorOsagie, Esosa
dc.contributor.authorIdemudia, Nosakhare L
dc.contributor.authorIgedegbe, Oghenero
dc.contributor.authorChukwumah, Nneka
dc.contributor.authorAdebiyi, Ruxton
dc.contributor.authorMann, Allison E
dc.contributor.authorO'Connell, Lauren M
dc.contributor.authorObuekwe, Ozo
dc.contributor.authorOmoigberale, Augustine
dc.contributor.authorCharurat, Manhattan E
dc.contributor.authorRichards, Vincent P
dc.date.accessioned2021-12-09T19:12:42Z
dc.date.available2021-12-09T19:12:42Z
dc.date.issued2021-12-04
dc.identifier.urihttp://hdl.handle.net/10713/17337
dc.description.abstractBackground: This study seeks to understand better the mechanisms underlying the increased risk of caries in HIV-infected school-aged Nigerian children by examining the relationship between the plaque microbiome and perinatal HIV infection and exposure. We also seek to investigate how perinatal HIV infection and exposure impact tooth-specific microbiomes' role on caries disease progression. Methods: The participants in this study were children aged 4 to 11 years recruited from the University of Benin Teaching Hospital (UBTH), Nigeria, between May to November 2019. Overall, 568 children were enrolled in three groups: 189 HIV-infected (HI), 189 HIV-exposed but uninfected (HEU) and 190 HIV-unexposed and uninfected (HUU) as controls at visit 1 with a 2.99% and 4.90% attrition rate at visit 2 and visit 3 respectively. Data were obtained with standardized questionnaires. Blood samples were collected for HIV, HBV and HCV screening; CD4, CD8 and full blood count analysis; and plasma samples stored for future investigations; oral samples including saliva, buccal swabs, oropharyngeal swab, tongue swab, dental plaque were collected aseptically from participants at different study visits. Conclusions: Results from the study will provide critical information on how HIV exposure, infection, and treatment, influence the oral microbiome and caries susceptibility in children. By determining the effect on community taxonomic structure and gene expression of dental microbiomes, we will elucidate mechanisms that potentially create a predisposition for developing dental caries. As future plans, the relationship between respiratory tract infections, immune and inflammatory markers with dental caries in perinatal HIV infection and exposure will be investigated.en_US
dc.description.urihttps://doi.org/10.1186/s12903-021-01944-yen_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofBMC Oral Healthen_US
dc.rights© 2021. The Author(s).en_US
dc.subjectCariesen_US
dc.subjectChildrenen_US
dc.subjectCohorten_US
dc.subjectDental plaqueen_US
dc.subjectHIVen_US
dc.subjectOral microbiomeen_US
dc.titleDental caries and its association with the oral microbiomes and HIV in young children-Nigeria (DOMHaIN): a cohort studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12903-021-01944-y
dc.identifier.pmid34863179
dc.source.volume21
dc.source.issue1
dc.source.beginpage620
dc.source.endpage
dc.source.countryUnited States
dc.source.countryEngland


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