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dc.contributor.authorSapone, Anna
dc.contributor.authorMartorelli, Luigi
dc.contributor.authorRusso, Maria Itria
dc.contributor.authorGeneroso, Maddalena
dc.contributor.authorEsposito, Pasquale
dc.contributor.authorde Magistris, Laura
dc.contributor.authorFerraraccio, Franca
dc.contributor.authorEsposito, Pasquale
dc.contributor.authorCarteni, Maria
dc.contributor.authorFasano, Alessio
dc.date.accessioned2012-07-16T15:23:20Z
dc.date.available2012-07-16T15:23:20Z
dc.date.issued2006
dc.identifier.urihttp://hdl.handle.net/10713/1727
dc.descriptionPowerPoint slides for the 2006 American Gastroenterological Association Conference. Author institutional affiliations: Seconda Universita degli Studi di Napoli and the Mucosal Biology Research Center, University of Maryland School of Medicine (Baltimore)en_US
dc.description.abstractBackground: Altered intestinal permeability values (IP) and intestinal ultra-structural abnormalities have been shown in cirrhotic patients as well as other liver diseases. Aims: To study the IP, serum levels of the intestinal tight junction (tj) modulator zonulin (Z), and the immunohystochemical [immunohistochemical] expression of junctional proteins occludin, claudin, desmoglein and intracellular actin in duodenal mucosa of HCV-CH patients. Methods: The Intestinal Permeability was evaluated by the Lactulose/Mannitol (LA/MA) test. Serum Zonulin levels were determined by sandwich-ELISA. Distal duodenum biopsies were obtained by EGDS and processed for immunohystochemistry [immunohistochemistry]. Staining was obtained with antibodies specific for occludin, claudin-4, desmoglein-3, and citoskeleton of actin. Conclusions: The increased Intestinal Permeability was detected in 32% of the HCV-CH patients studied and was associated to elevated serum Zonulin levels values. These changes were associated to modification of tj proteins expression and localization. Our data suggest that in a subgroup of HCV-CH patients the up-regulation of intestinal permeability-zonulin dependent may lead to increased non-self antigens access that may influence the course of the liver disease.en_US
dc.language.isoen_USen_US
dc.subjectintestinal permeability
dc.subject.meshHepatitis C, Chronic--physiopathology
dc.subject.meshImmunohistochemistry
dc.subject.meshTight Junctions
dc.titleImmunohistochemical expression of junctional proteins and intestinal permeability are altered in Hepatitis C virus (HCV) related chronic hepatitis (HCV-CH)en_US
dc.typePoster/Presentationen_US
dc.description.urinameFull Texten_US
refterms.dateFOA2019-02-20T14:53:09Z


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