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dc.contributor.authorSapone, Anna
dc.contributor.authorMartorelli, Luigi
dc.contributor.authorRusso, Maria Itria
dc.contributor.authorGeneroso, Maddalena
dc.contributor.authorEsposito, Pasquale
dc.contributor.authorde Magistris, Laura
dc.contributor.authorFerraraccio, Franca
dc.contributor.authorEsposito, Pasquale
dc.contributor.authorCarteni, Maria
dc.contributor.authorFasano, Alessio
dc.descriptionPowerPoint slides for the 2006 American Gastroenterological Association Conference. Author institutional affiliations: Seconda Universita degli Studi di Napoli and the Mucosal Biology Research Center, University of Maryland School of Medicine (Baltimore)en_US
dc.description.abstractBackground: Altered intestinal permeability values (IP) and intestinal ultra-structural abnormalities have been shown in cirrhotic patients as well as other liver diseases. Aims: To study the IP, serum levels of the intestinal tight junction (tj) modulator zonulin (Z), and the immunohystochemical [immunohistochemical] expression of junctional proteins occludin, claudin, desmoglein and intracellular actin in duodenal mucosa of HCV-CH patients. Methods: The Intestinal Permeability was evaluated by the Lactulose/Mannitol (LA/MA) test. Serum Zonulin levels were determined by sandwich-ELISA. Distal duodenum biopsies were obtained by EGDS and processed for immunohystochemistry [immunohistochemistry]. Staining was obtained with antibodies specific for occludin, claudin-4, desmoglein-3, and citoskeleton of actin. Conclusions: The increased Intestinal Permeability was detected in 32% of the HCV-CH patients studied and was associated to elevated serum Zonulin levels values. These changes were associated to modification of tj proteins expression and localization. Our data suggest that in a subgroup of HCV-CH patients the up-regulation of intestinal permeability-zonulin dependent may lead to increased non-self antigens access that may influence the course of the liver disease.en_US
dc.subjectintestinal permeability
dc.subject.meshHepatitis C, Chronic--physiopathology
dc.subject.meshTight Junctions
dc.titleImmunohistochemical expression of junctional proteins and intestinal permeability are altered in Hepatitis C virus (HCV) related chronic hepatitis (HCV-CH)en_US
dc.description.urinameFull Texten_US

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