• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Embryonal Rhabdomyosarcoma with Posttherapy Cytodifferentiation and Aggressive Clinical Course

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Jeyaraju, Maniraj
    Macatangay, Regina Ann
    Munchel, Ashley Taylor-King
    York, Teresa Anne
    Montgomery, Elizabeth A
    Kallen, Michael E
    Date
    2021-11-08
    Journal
    Case Reports in Pathology
    Publisher
    Elsevier Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1155/2021/1800854
    http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8592761/
    Abstract
    Rhabdomyosarcoma is the most common soft tissue sarcoma in children and adolescents. Embryonal rhabdomyosarcoma (ERMS), its most common subtype, is a malignant soft tissue tumor with morphologic and immunophenotypic features of embryonic skeletal muscle. The histologic findings in ERMS typically include a range of differentiation in rhabdomyoblasts from primitive to terminally differentiated forms, and the latter become more prominent after chemotherapy-induced cytodifferentiation. Several reports have shown therapy-related cytodifferentiation to portend a good prognosis in ERMS. We discuss the case of a pediatric patient who presented with ERMS of the orbit. Although her tumor showed extensive posttreatment cytodifferentiation and several other good prognostic clinicopathologic factors, it pursued an aggressive course, resulting in early metastasis and death. This case represents an unusual course and may be instructive as to the clinicopathologic features impacting prognostication, and ultimately the biology, of this aggressive family of tumors.
    Rights/Terms
    Copyright © 2021 Maniraj Jeyaraju et al.
    Keyword
    Child, Preschool
    Rhabdomyosarcoma--pathology
    Case Reports
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17267
    ae974a485f413a2113503eed53cd6c53
    10.1155/2021/1800854
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Pathologic features of rhabdomyosarcoma before and after treatment: a clinicopathologic and immunohistochemical analysis.
    • Authors: Coffin CM, Rulon J, Smith L, Bruggers C, White FV
    • Issue date: 1997 Dec
    • [Rhabdomyosarcoma: morphology and cellular differentiation].
    • Authors: Schmidt D, Harms D, Reimann O, Treuner J
    • Issue date: 1986 May-Jun
    • Cytodifferentiation and clinical outcome after chemotherapy and radiation therapy for rhabdomyosarcoma (RMS).
    • Authors: Smith LM, Anderson JR, Coffin CM
    • Issue date: 2002 Jun
    • Cellular differentiation and prognosis in embryonal rhabdomyosarcoma. A report from the Cooperative Soft Tissue Sarcoma Study 1981 (CWS 81).
    • Authors: Schmidt D, Reimann O, Treuner J, Harms D
    • Issue date: 1986
    • Sclerosing rhabdomyosarcoma in adults: report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma, or angiosarcoma.
    • Authors: Folpe AL, McKenney JK, Bridge JA, Weiss SW
    • Issue date: 2002 Sep
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.