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    Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases

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    Author
    Fishman, Paul S
    Fischell, Johnathan M
    Date
    2021-11-04
    Journal
    Frontiers in Neurology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fneur.2021.749047
    Abstract
    The blood brain barrier (BBB) is an obstacle for the delivery of potential molecular therapies for neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). Although there has been a proliferation of potential disease modifying therapies for these progressive conditions, strategies to deliver these large agents remain limited. High intensity MRI guided focused ultrasound has already been FDA approved to lesion brain targets to treat movement disorders, while lower intensity pulsed ultrasound coupled with microbubbles commonly used as contrast agents can create transient safe opening of the BBB. Pre-clinical studies have successfully delivered growth factors, antibodies, genes, viral vectors, and nanoparticles in rodent models of AD and PD. Recent small clinical trials support the safety and feasibility of this strategy in these vulnerable patients. Further study is needed to establish safety as MRI guided BBB opening is used to enhance the delivery of newly developed molecular therapies.
    Rights/Terms
    Copyright © 2021 Fishman and Fischell.
    Keyword
    Alzheimer's disease
    FUS
    Parkinson's disease
    blood-brain barrier
    focused ultrasound (MRgFUS)
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17255
    ae974a485f413a2113503eed53cd6c53
    10.3389/fneur.2021.749047
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