Imaging and Electrophysiology for Degenerative Cervical Myelopathy [AO Spine RECODE DCM Research Priority Number 9]
AuthorMartin, Allan R
Davies, Benjamin M
Wilson, Jefferson R
Fehlings, Michael G
Kwon, Brian K
Harrop, James S
Davies, Benjamin M
Kotter, Mark Rn
Guest, James D
Kurpad, Shekar N
JournalGlobal Spine Journal
PublisherSAGE Publications Inc.
MetadataShow full item record
AbstractStudy Design: Narrative review. Objective: The current review aimed to describe the role of existing techniques and emerging methods of imaging and electrophysiology for the management of degenerative cervical myelopathy (DCM), a common and often progressive condition that causes spinal cord dysfunction and significant morbidity globally. Methods: A narrative review was conducted to summarize the existing literature and highlight future directions. Results: Anatomical magnetic resonance imaging (MRI) is well established in the literature as the key imaging tool to identify spinal cord compression, disc herniation/bulging, and inbuckling of the ligamentum flavum, thus facilitating surgical planning, while radiographs and computed tomography (CT) provide complimentary information. Electrophysiology techniques are primarily used to rule out competing diagnoses. However, signal change and measures of cord compression on conventional MRI have limited utility to characterize the degree of tissue injury, which may be helpful for diagnosis, prognostication, and repeated assessments to identify deterioration. Early translational studies of quantitative imaging and electrophysiology techniques show potential of these methods to more accurately reflect changes in spinal cord microstructure and function. Conclusion: Currently, clinical management of DCM relies heavily on anatomical MRI, with additional contributions from radiographs, CT, and electrophysiology. Novel quantitative assessments of microstructure, perfusion, and function have the potential to transform clinical practice, but require robust validation, automation, and standardization prior to uptake. © The Author(s) 2021.
spinal cord compression
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/17228
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- Authors: Tetreault L, Garwood P, Gharooni AA, Touzet AY, Nanna-Lohkamp L, Martin A, Wilson J, Harrop JS, Guest J, Kwon BK, Milligan J, Arizala AM, Riew KD, Fehlings MG, Kotter MR, Kalsi-Ryan S, Davies B
- Issue date: 2021 Dec 31
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- Authors: Mowforth OD, Khan DZ, Wong MY, Pickering GAE, Dean L, Magee J, Mullarkey L, Hirayama Y, Rihova M, Butler M, Stewart M, Goulson B, Ahmed S, Fricke K, Popa-Nimigean V, Millar Z, Venkatesh A, Willison A, Senthil K, Hazenbiller O, Sarewitz E, Sadler I, Gronlund T, Tetreault L, Harrop JS, Aarabi B, Rahimi-Movaghar V, Kurpad SN, Guest JD, Wilson JR, Kwon BK, Fehlings MG, McNair AGK, Davies BM, Kotter MRN
- Issue date: 2021 Dec 8
- The development of lived experience-centered word clouds to support research uncertainty gathering in degenerative cervical myelopathy: results from an engagement process and protocol for their evaluation, via a nested randomized controlled trial.
- Authors: Davies BM, Mowforth OD, Khan DZ, Yang X, Stacpoole SRL, Hazenbiller O, Gronlund T, Tetreault L, Kalsi-Ryan S, Starkey ML, Sadler I, Sarewitz E, Houlton D, Carter J, Howard E, Rahimi-Movaghar V, Guest JD, Aarabi B, Kwon BK, Kurpad SN, Harrop J, Wilson JR, Grossman R, Smith EK, McNair AGK, Fehlings MG, Kotter MRN
- Issue date: 2021 Jun 25
- Increasing awareness of degenerative cervical myelopathy: a preventative cause of non-traumatic spinal cord injury.
- Authors: Zipser CM, Margetis K, Pedro KM, Curt A, Fehlings M, Sadler I, Tetreault L, Davies BM, AO Spine RECODE DCM Steering Committee., Members of the Diagnostic Criteria Working Group.
- Issue date: 2021 Nov
- Prevailing Outcome Themes Reported by People With Degenerative Cervical Myelopathy: Focus Group Study.
- Authors: Khan DZ, Fitzpatrick SM, Hilton B, McNair AG, Sarewitz E, Davies BM, Kotter MR, AO Spine Knowledge Forum Spinal Cord Injury.
- Issue date: 2021 Feb 3