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dc.contributor.authorLi, Fenfen
dc.contributor.authorJing, Jia
dc.contributor.authorMovahed, Miranda
dc.contributor.authorCui, Xin
dc.contributor.authorCao, Qiang
dc.contributor.authorWu, Rui
dc.contributor.authorChen, Ziyue
dc.contributor.authorYu, Liqing
dc.contributor.authorPan, Yi
dc.contributor.authorShi, Huidong
dc.contributor.authorShi, Hang
dc.contributor.authorXue, Bingzhong
dc.date.accessioned2021-11-30T19:23:04Z
dc.date.available2021-11-30T19:23:04Z
dc.date.issued2021-11-25
dc.identifier.urihttp://hdl.handle.net/10713/17226
dc.description.abstractBrown adipocytes share the same developmental origin with skeletal muscle. Here we find that a brown adipocyte-to-myocyte remodeling also exists in mature brown adipocytes, and is induced by prolonged high fat diet (HFD) feeding, leading to brown fat dysfunction. This process is regulated by the interaction of epigenetic pathways involving histone and DNA methylation. In mature brown adipocytes, the histone demethylase UTX maintains persistent demethylation of the repressive mark H3K27me3 at Prdm16 promoter, leading to high Prdm16 expression. PRDM16 then recruits DNA methyltransferase DNMT1 to Myod1 promoter, causing Myod1 promoter hypermethylation and suppressing its expression. The interaction between PRDM16 and DNMT1 coordinately serves to maintain brown adipocyte identity while repressing myogenic remodeling in mature brown adipocytes, thus promoting their active brown adipocyte thermogenic function. Suppressing this interaction by HFD feeding induces brown adipocyte-to-myocyte remodeling, which limits brown adipocyte thermogenic capacity and compromises diet-induced thermogenesis, leading to the development of obesity.en_US
dc.description.urihttps://doi.org/10.1038/s41467-021-27141-7en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofNature Communicationsen_US
dc.rights© 2021. The Author(s).en_US
dc.subjectmyogenic remodelingen_US
dc.subject.meshAdipocytes, Brownen_US
dc.subject.meshDiet, High Fat--adverse effectsen_US
dc.subject.meshObesity--etiologyen_US
dc.titleEpigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown faten_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41467-021-27141-7
dc.identifier.pmid34824202
dc.source.volume12
dc.source.issue1
dc.source.beginpage6838
dc.source.endpage
dc.source.countryEngland


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