A non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals
Author
Gerson, Kristin DLiao, Jingqiu
McCarthy, Clare
Burris, Heather H
Korem, Tal
Levy, Maayan
Ravel, Jacques
Elovitz, Michal A
Date
2021-11-23Journal
Scientific ReportsPublisher
Springer NatureType
Article
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Biomechanical and molecular processes of premature cervical remodeling preceding spontaneous preterm birth (sPTB) likely result from interactions between the cervicovaginal microbiota and host immune responses. A non-optimal cervicovaginal microbiota confers increased risk of sPTB. The cervicovaginal space is metabolically active in pregancy; microbiota can produce, modify, and degrade metabolites within this ecosystem. We establish that cervicovaginal metabolomic output clusters by microbial community in pregnancy among Black individuals, revealing increased metabolism within the amino acid and dipeptide pathways as hallmarks of a non-optimal microbiota. Few differences were detected in metabolomic profiles when stratified by birth outcome. The study raises the possibility that metabolites could distinguish women with greater risk of sPTB among those with similar cervicovaginal microbiota, and that metabolites within the amino acid and carbohydrate pathways may play a role in this distinction.Rights/Terms
© 2021. The Author(s).Identifier to cite or link to this item
http://hdl.handle.net/10713/17218ae974a485f413a2113503eed53cd6c53
10.1038/s41598-021-02304-0
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