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    A non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals

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    Author
    Gerson, Kristin D
    Liao, Jingqiu
    McCarthy, Clare
    Burris, Heather H
    Korem, Tal
    Levy, Maayan
    Ravel, Jacques
    Elovitz, Michal A
    Date
    2021-11-23
    Journal
    Scientific Reports
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://www.nature.com/articles/s41598-021-02304-0
    Abstract
    Biomechanical and molecular processes of premature cervical remodeling preceding spontaneous preterm birth (sPTB) likely result from interactions between the cervicovaginal microbiota and host immune responses. A non-optimal cervicovaginal microbiota confers increased risk of sPTB. The cervicovaginal space is metabolically active in pregancy; microbiota can produce, modify, and degrade metabolites within this ecosystem. We establish that cervicovaginal metabolomic output clusters by microbial community in pregnancy among Black individuals, revealing increased metabolism within the amino acid and dipeptide pathways as hallmarks of a non-optimal microbiota. Few differences were detected in metabolomic profiles when stratified by birth outcome. The study raises the possibility that metabolites could distinguish women with greater risk of sPTB among those with similar cervicovaginal microbiota, and that metabolites within the amino acid and carbohydrate pathways may play a role in this distinction.
    Rights/Terms
    © 2021. The Author(s).
    Keyword
    cervicovaginal microbiota
    Premature Birth--microbiology
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17218
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-021-02304-0
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