Show simple item record

dc.contributor.authorBurns, Carol J
dc.contributor.authorLaKind, Judy S
dc.date.accessioned2021-11-30T14:42:26Z
dc.date.available2021-11-30T14:42:26Z
dc.date.issued2021-11-19
dc.identifier.urihttp://hdl.handle.net/10713/17206
dc.description.abstractBackground: The Matrix is designed to facilitate discussions between practitioners of risk assessment and epidemiology and, in so doing, to enhance the utility of epidemiology research for public health decision-making. The Matrix is comprised of nine fundamental “asks” of epidemiology studies, focusing on the types of information valuable to the risk assessment process. Objective: A 2,4-dichlorophenoxyacetic acid (2,4-D) case study highlights the extent to which existing epidemiology literature includes information generally needed for risk assessments and proffers suggestions that would assist in bridging the epidemiology/risk assessment gap. Methods: Thirty-one publications identified in the US Environmental Protection Agency 2,4-D epidemiology review were assessed. These studies focused on associations between 2,4-D exposure and non-Hodgkin lymphoma (NHL), respiratory effects, and birth outcomes. Results: Many of the papers met one or more specific elements of the Matrix. However, from this case study, it is clear that some aspects of risk assessment, such as evaluating source-to-intake pathways, are generally not considered in epidemiology research. Others are incorporated, but infrequently (e.g. dose-response information, harmonization of exposure categories). We indicated where additional analyses or modifications to future study design could serve to improve the translation. Discussion: Interaction with risk assessors during the study design phase and using the Matrix “asks” to guide the conversations could shape research and provide the basis for requests for funds to support these additional activities. The use of the Matrix as a foundation for communication and education across disciplines could produce more impactful and consequential epidemiology research for robust risk assessments and decision-making. © 2021 The Author(s).en_US
dc.description.urihttps://doi.org/10.1080/10408444.2021.1997911en_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Inc.en_US
dc.relation.ispartofCritical Reviews in Toxicologyen_US
dc.subject2,4-Den_US
dc.subjectcausalityen_US
dc.subjectepidemiologyen_US
dc.subjectexposure assessmenten_US
dc.subjectmatrixen_US
dc.subjectpesticidesen_US
dc.subjectrisk assessmenten_US
dc.titleUsing the Matrix to bridge the epidemiology/risk assessment gap: a case study of 2,4-Den_US
dc.typeArticleen_US
dc.identifier.doi10.1080/10408444.2021.1997911
dc.identifier.pmid34796780
dc.source.beginpage1
dc.source.endpage9
dc.source.countryEngland


This item appears in the following Collection(s)

Show simple item record