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dc.contributor.authorKarki, Pratap
dc.contributor.authorBirukova, Anna A
dc.date.accessioned2021-11-18T18:48:26Z
dc.date.available2021-11-18T18:48:26Z
dc.date.issued2021-10-28
dc.identifier.urihttp://hdl.handle.net/10713/17154
dc.description.abstractEndothelial dysfunction has been attributed as one of the major complications in COVID-19 patients, a global pandemic that has already caused over 4 million deaths worldwide. The dysfunction of endothelial barrier is characterized by an increase in endothelial permeability and inflammatory responses, and has even broader implications in the pathogenesis of acute respiratory syndromes such as ARDS, sepsis and chronic illnesses represented by pulmonary arterial hypertension and interstitial lung disease. The structural integrity of endothelial barrier is maintained by cytoskeleton elements, cell-substrate focal adhesion and adhesive cell junctions. Agonist-mediated changes in endothelial permeability are directly associated with reorganization of actomyosin cytoskeleton leading to cell contraction and opening of intercellular gaps or enhancement of cortical actin cytoskeleton associated with strengthening of endothelial barrier. The role of actin cytoskeleton remodeling in endothelial barrier regulation has taken the central stage, but the impact of microtubules in this process remains less explored and under-appreciated. This review will summarize the current knowledge on the crosstalk between microtubules dynamics and actin cytoskeleton remodeling, describe the signaling mechanisms mediating this crosstalk, discuss epigenetic regulation of microtubules stability and its nexus with endothelial barrier maintenance, and overview a role of microtubules in targeted delivery of signaling molecules regulating endothelial permeability and inflammation.en_US
dc.description.urihttps://doi.org/10.3389/fphys.2021.758313en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Physiologyen_US
dc.rightsCopyright © 2021 Karki and Birukova.en_US
dc.subjectacute lung injuryen_US
dc.subjectcytoskeletal remodelingen_US
dc.subjectendothelial barrieren_US
dc.subjecthistone deacetylaseen_US
dc.subjectinflammationen_US
dc.subjectmicrotubulesen_US
dc.titleMicrotubules as Major Regulators of Endothelial Function: Implication for Lung Injuryen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fphys.2021.758313
dc.identifier.pmid34777018
dc.source.volume12
dc.source.beginpage758313
dc.source.endpage
dc.source.countrySwitzerland


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