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    The Saudi Critical Care Society practice guidelines on the management of COVID-19 in the ICU: Therapy section

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    Author
    Alhazzani, Waleed
    Alshahrani, Mohammed
    Alshamsi, Fayez
    Aljuhani, Ohoud
    Eljaaly, Khalid
    Hashim, Samaher
    Alqahtani, Rakan
    Alsaleh, Doaa
    Al Duhailib, Zainab
    Algethamy, Haifa
    Al-Musawi, Tariq
    Alshammari, Thamir
    Alqarni, Abdullah
    Khoujah, Danya
    Tashkandi, Wail
    Dahhan, Talal
    Almutairi, Najla
    Alserehi, Haleema A
    Al-Yahya, Maytha
    Al-Judaibi, Bandar
    Arabi, Yaseen M
    Abualenain, Jameel
    Alotaibi, Jawaher M
    Al bshabshe, Ali
    Alharbi, Reham
    Al-Hameed, Fahad
    Elhazmi, Alyaa
    Almaghrabi, Reem S
    Almaghlouth, Fatma
    Abedalthagafi, Malak
    Al Khathlan, Noor
    Al-Suwaidan, Faisal A
    Bunyan, Reem F
    Baw, Bandar
    Alghamdi, Ghassan
    Al Hazmi, Manal
    Mandourah, Yasser
    Assiri, Abdullah
    Enani, Mushira
    Alawi, Maha
    Aljindan, Reem
    Aljabbary, Ahmed
    Alrbiaan, Abdullah
    Algurashi, Fahd
    Alsaawi, Abdulmohsen
    Alenazi, Thamer H
    Alsultan, Mohammed A
    Alqahtani, Saleh A
    Memish, Ziad
    Al-Tawfiq, Jaffar A
    Al-jedai, Ahmed
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    Date
    2021-10-20
    Journal
    Journal of Infection and Public Health
    Publisher
    Elsevier Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1016/j.jiph.2021.10.005
    Abstract
    Background: The rapid increase in coronavirus disease 2019 (COVID-19) cases during the subsequent waves in Saudi Arabia and other countries prompted the Saudi Critical Care Society (SCCS) to put together a panel of experts to issue evidence-based recommendations for the management of COVID-19 in the intensive care unit (ICU). Methods: The SCCS COVID-19 panel included 51 experts with expertise in critical care, respirology, infectious disease, epidemiology, emergency medicine, clinical pharmacy, nursing, respiratory therapy, methodology, and health policy. All members completed an electronic conflict of interest disclosure form. The panel addressed 9 questions that are related to the therapy of COVID-19 in the ICU. We identified relevant systematic reviews and clinical trials, then used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach as well as the evidence-to-decision framework (EtD) to assess the quality of evidence and generate recommendations. Results: The SCCS COVID-19 panel issued 12 recommendations on pharmacotherapeutic interventions (immunomodulators, antiviral agents, and anticoagulants) for severe and critical COVID-19, of which 3 were strong recommendations and 9 were weak recommendations. Conclusion: The SCCS COVID-19 panel used the GRADE approach to formulate recommendations on therapy for COVID-19 in the ICU. The EtD framework allows adaptation of these recommendations in different contexts. The SCCS guideline committee will update recommendations as new evidence becomes available.
    Rights/Terms
    Copyright © 2021. Published by Elsevier Ltd.
    Keyword
    COVID-19
    Intensive care unit
    Practice guideline
    Therapy
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17145
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jiph.2021.10.005
    Scopus Count
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    UMB Coronavirus Publications
    UMB Open Access Articles

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