The Saudi Critical Care Society practice guidelines on the management of COVID-19 in the ICU: Therapy section
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Author
Alhazzani, WaleedAlshahrani, Mohammed
Alshamsi, Fayez
Aljuhani, Ohoud
Eljaaly, Khalid
Hashim, Samaher
Alqahtani, Rakan
Alsaleh, Doaa
Al Duhailib, Zainab
Algethamy, Haifa
Al-Musawi, Tariq
Alshammari, Thamir
Alqarni, Abdullah
Khoujah, Danya
Tashkandi, Wail
Dahhan, Talal
Almutairi, Najla
Alserehi, Haleema A
Al-Yahya, Maytha
Al-Judaibi, Bandar
Arabi, Yaseen M
Abualenain, Jameel
Alotaibi, Jawaher M
Al bshabshe, Ali
Alharbi, Reham
Al-Hameed, Fahad
Elhazmi, Alyaa
Almaghrabi, Reem S
Almaghlouth, Fatma
Abedalthagafi, Malak
Al Khathlan, Noor
Al-Suwaidan, Faisal A
Bunyan, Reem F
Baw, Bandar
Alghamdi, Ghassan
Al Hazmi, Manal
Mandourah, Yasser
Assiri, Abdullah
Enani, Mushira
Alawi, Maha
Aljindan, Reem
Aljabbary, Ahmed
Alrbiaan, Abdullah
Algurashi, Fahd
Alsaawi, Abdulmohsen
Alenazi, Thamer H
Alsultan, Mohammed A
Alqahtani, Saleh A
Memish, Ziad
Al-Tawfiq, Jaffar A
Al-jedai, Ahmed
Date
2021-10-20Journal
Journal of Infection and Public HealthPublisher
Elsevier Inc.Type
Article
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Background: The rapid increase in coronavirus disease 2019 (COVID-19) cases during the subsequent waves in Saudi Arabia and other countries prompted the Saudi Critical Care Society (SCCS) to put together a panel of experts to issue evidence-based recommendations for the management of COVID-19 in the intensive care unit (ICU). Methods: The SCCS COVID-19 panel included 51 experts with expertise in critical care, respirology, infectious disease, epidemiology, emergency medicine, clinical pharmacy, nursing, respiratory therapy, methodology, and health policy. All members completed an electronic conflict of interest disclosure form. The panel addressed 9 questions that are related to the therapy of COVID-19 in the ICU. We identified relevant systematic reviews and clinical trials, then used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach as well as the evidence-to-decision framework (EtD) to assess the quality of evidence and generate recommendations. Results: The SCCS COVID-19 panel issued 12 recommendations on pharmacotherapeutic interventions (immunomodulators, antiviral agents, and anticoagulants) for severe and critical COVID-19, of which 3 were strong recommendations and 9 were weak recommendations. Conclusion: The SCCS COVID-19 panel used the GRADE approach to formulate recommendations on therapy for COVID-19 in the ICU. The EtD framework allows adaptation of these recommendations in different contexts. The SCCS guideline committee will update recommendations as new evidence becomes available.Rights/Terms
Copyright © 2021. Published by Elsevier Ltd.Identifier to cite or link to this item
http://hdl.handle.net/10713/17145ae974a485f413a2113503eed53cd6c53
10.1016/j.jiph.2021.10.005
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