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    Characteristics, Comorbidities, and Outcomes in a Multicenter Registry of Patients With Human Immunodeficiency Virus and Coronavirus Disease 2019

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    Author
    Dandachi, Dima
    Geiger, Grant
    Montgomery, Mary W
    Karmen-Tuohy, Savannah
    Golzy, Mojgan
    Antar, Annukka A R
    Llibre, Josep M
    Camazine, Maraya
    Díaz-De Santiago, Alberto
    Carlucci, Philip M
    Zacharioudakis, Ioannis M
    Rahimian, Joseph
    Wanjalla, Celestine N
    Slim, Jihad
    Arinze, Folasade
    Kratz, Ann Marie Porreca
    Jones, Joyce L
    Patel, Shital M
    Kitchell, Ellen
    Francis, Adero
    Ray, Manoj
    Koren, David E
    Baddley, John W
    Hill, Brannon
    Sax, Paul E
    Chow, Jeremy
    Show allShow less

    Date
    2020-09-09
    Journal
    Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/cid/ciaa1339
    http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7499544/
    Abstract
    BACKGROUND: People living with human immunodeficiency virus (HIV) may have numerous risk factors for acquiring coronavirus disease 2019 (COVID-19) and developing severe outcomes, but current data are conflicting. METHODS: Health-care providers enrolled consecutively, by nonrandom sampling, people living with HIV (PWH) with lab-confirmed COVID-19, diagnosed at their facilities between 1 April and 1 July 2020. Deidentified data were entered into an electronic Research Electronic Data Capture (REDCap) system. The primary endpoint was a severe outcome, defined as a composite endpoint of intensive care unit (ICU) admission, mechanical ventilation, or death. The secondary outcome was the need for hospitalization. RESULTS: There were 286 patients included; the mean age was 51.4 years (standard deviation, 14.4), 25.9% were female, and 75.4% were African American or Hispanic. Most patients (94.3%) were on antiretroviral therapy, 88.7% had HIV virologic suppression, and 80.8% had comorbidities. Within 30 days of testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 164 (57.3%) patients were hospitalized, and 47 (16.5%) required ICU admission. Mortality rates were 9.4% (27/286) overall, 16.5% (27/164) among those hospitalized, and 51.5% (24/47) among those admitted to an ICU. The primary composite endpoint occurred in 17.5% (50/286) of all patients and 30.5% (50/164) of hospitalized patients. Older age, chronic lung disease, and hypertension were associated with severe outcomes. A lower CD4 count (<200 cells/mm3) was associated with the primary and secondary endpoints. There were no associations between the ART regimen or lack of viral suppression and the predefined outcomes. CONCLUSIONS: Severe clinical outcomes occurred commonly in PWH with COVID-19. The risks for poor outcomes were higher in those with comorbidities and lower CD4 cell counts, despite HIV viral suppression. CLINICAL TRIALS REGISTRATION: NCT04333953. © The Author(s) 2020.
    Rights/Terms
    © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
    Keyword
    AIDS
    COVID-19
    HIV
    SARS-CoV-2
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17092
    ae974a485f413a2113503eed53cd6c53
    10.1093/cid/ciaa1339
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