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dc.contributor.authorSun, Daokun
dc.contributor.authorRichard, Melissa
dc.contributor.authorMusani, Solomon K
dc.contributor.authorSung, Yun Ju
dc.contributor.authorWinkler, Thomas W
dc.contributor.authorSchwander, Karen
dc.contributor.authorChai, Jin Fang
dc.contributor.authorGuo, Xiuqing
dc.contributor.authorKilpeläinen, Tuomas O
dc.contributor.authorVojinovic, Dina
dc.contributor.authorAschard, Hugues
dc.contributor.authorBartz, Traci M
dc.contributor.authorBielak, Lawrence F
dc.contributor.authorBrown, Michael R
dc.contributor.authorChitrala, Kumaraswamy
dc.contributor.authorHartwig, Fernando P
dc.contributor.authorHorimoto, Andrea R V R
dc.contributor.authorLiu, Yongmei
dc.contributor.authorManning, Alisa K
dc.contributor.authorNoordam, Raymond
dc.contributor.authorSmith, Albert V
dc.contributor.authorHarris, Sarah E
dc.contributor.authorKühnel, Brigitte
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorNolte, Ilja M
dc.contributor.authorRauramaa, Rainer
dc.contributor.authorvan der Most, Peter J
dc.contributor.authorWang, Rujia
dc.contributor.authorWare, Erin B
dc.contributor.authorWeiss, Stefan
dc.contributor.authorWen, Wanqing
dc.contributor.authorYanek, Lisa R
dc.contributor.authorArking, Dan E
dc.contributor.authorArnett, Donna K
dc.contributor.authorBarac, Ana
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorBroeckel, Ulrich
dc.contributor.authorChakravarti, Aravinda
dc.contributor.authorChen, Yii-Der Ida
dc.contributor.authorCupples, L Adrienne
dc.contributor.authorDavigulus, Martha L
dc.contributor.authorde Las Fuentes, Lisa
dc.contributor.authorde Mutsert, Renée
dc.contributor.authorde Vries, Paul S
dc.contributor.authorDelaney, Joseph A C
dc.contributor.authorRoux, Ana V Diez
dc.contributor.authorDörr, Marcus
dc.contributor.authorFaul, Jessica D
dc.contributor.authorFretts, Amanda M
dc.contributor.authorGallo, Linda C
dc.contributor.authorGrabe, Hans Jörgen
dc.contributor.authorGu, C Charles
dc.contributor.authorHarris, Tamara B
dc.contributor.authorHartman, Catharina C A
dc.contributor.authorHeikkinen, Sami
dc.contributor.authorIkram, M Arfan
dc.contributor.authorIsasi, Carmen
dc.contributor.authorJohnson, W Craig
dc.contributor.authorJonas, Jost Bruno
dc.contributor.authorKaplan, Robert C
dc.contributor.authorKomulainen, Pirjo
dc.contributor.authorKrieger, Jose E
dc.contributor.authorLevy, Daniel
dc.contributor.authorLiu, Jianjun
dc.contributor.authorLohman, Kurt
dc.contributor.authorLuik, Annemarie I
dc.contributor.authorMartin, Lisa W
dc.contributor.authorMeitinger, Thomas
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorO'Connell, Jeff R
dc.contributor.authorPalmas, Walter R
dc.contributor.authorPeters, Annette
dc.contributor.authorPeyser, Patricia A
dc.contributor.authorPulkki-Råback, Laura
dc.contributor.authorRaffel, Leslie J
dc.contributor.authorReiner, Alex P
dc.contributor.authorRice, Kenneth
dc.contributor.authorRobinson, Jennifer G
dc.contributor.authorRosendaal, Frits R
dc.contributor.authorSchmidt, Carsten Oliver
dc.contributor.authorSchreiner, Pamela J
dc.contributor.authorSchwettmann, Lars
dc.contributor.authorShikany, James M
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorSidney, Stephen
dc.contributor.authorSims, Mario
dc.contributor.authorSmith, Jennifer A
dc.contributor.authorSotoodehnia, Nona
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorTai, E Shyong
dc.contributor.authorTaylor, Kent
dc.contributor.authorUitterlinden, André G
dc.contributor.authorvan Duijn, Cornelia M
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorWee, Hwee-Lin
dc.contributor.authorWei, Wen-Bin
dc.contributor.authorWilson, Gregory
dc.contributor.authorXuan, Deng
dc.contributor.authorYao, Jie
dc.contributor.authorZeng, Donglin
dc.contributor.authorZhao, Wei
dc.contributor.authorZhu, Xiaofeng
dc.contributor.authorZonderman, Alan B
dc.contributor.authorBecker, Diane M
dc.contributor.authorDeary, Ian J
dc.contributor.authorGieger, Christian
dc.contributor.authorLakka, Timo A
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorNorth, Kari E
dc.contributor.authorOldehinkel, Albertine J
dc.contributor.authorPenninx, Brenda W J H
dc.contributor.authorSnieder, Harold
dc.contributor.authorWang, Ya-Xing
dc.contributor.authorWeir, David R
dc.contributor.authorZheng, Wei
dc.contributor.authorEvans, Michele K
dc.contributor.authorGauderman, W James
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHorta, Bernardo L
dc.contributor.authorLiu, Ching-Ti
dc.contributor.authorMook-Kanamori, Dennis O
dc.contributor.authorMorrison, Alanna C
dc.contributor.authorPereira, Alexandre C
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorAmin, Najaf
dc.contributor.authorFox, Ervin R
dc.contributor.authorKooperberg, Charles
dc.contributor.authorSim, Xueling
dc.contributor.authorBierut, Laura
dc.contributor.authorRotter, Jerome I
dc.contributor.authorKardia, Sharon L R
dc.contributor.authorFranceschini, Nora
dc.contributor.authorRao, Dabeeru C
dc.contributor.authorFornage, Myriam
dc.date.accessioned2021-11-09T19:17:38Z
dc.date.available2021-11-09T19:17:38Z
dc.date.issued2020-10-31
dc.identifier.urihttp://hdl.handle.net/10713/17086
dc.description.abstractPsychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from 5 ancestry groups. In the combined meta-analyses of Stages 1 and 2, we identified 59 loci (p value <5e-8), including nine novel BP loci. The novel associations were observed mostly with pulse pressure, with fewer observed with mean arterial pressure. Five novel loci were identified in African ancestry, and all but one showed patterns of interaction with at least one psychosocial factor. Functional annotation of the novel loci supports a major role for genes implicated in the immune response (PLCL2), synaptic function and neurotransmission (LIN7A, PFIA2), as well as genes previously implicated in neuropsychiatric or stress-related disorders (FSTL5, CHODL). These findings underscore the importance of considering psychological and social factors in gene discovery for BP, especially in non-European populations.en_US
dc.description.urihttps://doi.org/10.1016/j.xhgg.2020.100013en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/34734193/en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofHGG Advancesen_US
dc.subjectpsychosocial factorsen_US
dc.subject.meshBlood Pressure--geneticsen_US
dc.subject.meshGenome-Wide Association Studyen_US
dc.titleMulti-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traitsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.xhgg.2020.100013
dc.identifier.pmid34734193
dc.source.volume2
dc.source.issue1
dc.source.countryUnited States


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