• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Dopaminergic Basis of Spatial Deficits in Early Parkinson's Disease

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Hanna-Pladdy, B
    Pahwa, R
    Lyons, K E
    Date
    2021-06-24
    Journal
    Cerebral Cortex Communications
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/texcom/tgab042
    http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8436572/
    Abstract
    Dopaminergic mechanisms regulating cognitive and motor control were evaluated comparing visuoperceptual and perceptuomotor functions in Parkinson's disease (PD). The performance of PD patients (n = 40) was contrasted with healthy controls (n = 42) across two separate visits (on and off dopaminergic medications) on computerized tasks of perception and aiming to a target at variable stimulus lengths (4, 8, 12 cm). Novel visuoperceptual tasks of length equivalence and width interval estimations without motor demands were compared with tasks estimating spatial deviation in movement termination. The findings support the presence of spatial deficits in early PD, more pronounced with increased discrimination difficulty, and with shorter stimulus lengths of 4 cm for both visuoperceptual and perceptumotor functions. Dopaminergic medication had an adverse impact on visuoperceptual accuracy in particular for length equivalence estimations, in contrast with dopaminergic modulation of perceptuomotor functions that reduced angular displacements toward the target. The differential outcomes for spatial accuracy in perception versus movement termination in PD are consistent with involvement of the direct pathway and models of progressive loss of dopamine through corticostriatal loops. Future research should develop validated and sensitive standardized tests of perception and explore dopaminergic selective deficits in PD to optimize medication titration for motor and cognitive symptoms of the disease.
    Rights/Terms
    Published by Oxford University Press 2021.
    Keyword
    Parkinson Disease
    dopaminergic modulation
    movement velocity
    spatial accuracy
    visuoperceptual
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17085
    ae974a485f413a2113503eed53cd6c53
    10.1093/texcom/tgab042
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Differential effects of dopaminergic medication on basic motor performance and executive functions in Parkinson's disease.
    • Authors: Michely J, Barbe MT, Hoffstaedter F, Timmermann L, Eickhoff SB, Fink GR, Grefkes C
    • Issue date: 2012 Aug
    • Different effects of dopaminergic medication on perceptual decision-making in Parkinson's disease as a function of task difficulty and speed-accuracy instructions.
    • Authors: Huang YT, Georgiev D, Foltynie T, Limousin P, Speekenbrink M, Jahanshahi M
    • Issue date: 2015 Aug
    • Dopaminergic contributions to distance estimation in Parkinson's disease: a sensory-perceptual deficit?
    • Authors: Ehgoetz Martens KA, Ellard CG, Almeida QJ
    • Issue date: 2013 Jul
    • Dissociable effects of dopaminergic therapy on spatial versus non-spatial working memory in Parkinson's disease.
    • Authors: Mollion H, Ventre-Dominey J, Dominey PF, Broussolle E
    • Issue date: 2003
    • Impact of dopamine and cognitive impairment on neural reactivity to facial emotion in Parkinson's disease.
    • Authors: Dan R, Růžička F, Bezdicek O, Roth J, Růžička E, Vymazal J, Goelman G, Jech R
    • Issue date: 2019 Nov
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.