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dc.contributor.authorRebechi, Melanie T
dc.contributor.authorBork, Jacqueline T
dc.contributor.authorRiedel, David J
dc.date.accessioned2021-11-09T19:11:00Z
dc.date.available2021-11-09T19:11:00Z
dc.date.issued2021-09-24
dc.identifier.urihttp://hdl.handle.net/10713/17084
dc.description.abstractHuman herpesvirus 6 (HHV-6) reactivation can occur in patients who are highly immunosuppressed, including those who have undergone hematopoietic stem cell transplantation (HSCT). HHV-6 encephalitis is a severe manifestation that is well described in the HSCT population. Chimeric antigen receptor T-cell (CAR-T) therapy is a novel cancer-directed immunotherapy that results in severe immunosuppression. Patients undergoing CAR-T therapy may be at risk for HHV-6 encephalitis, which can be difficult to distinguish from a common adverse effect of CAR-T therapy, neurotoxicity. Herein, we describe 2 patients diagnosed with HHV-6 encephalitis after CAR-T therapy and discuss the diagnostic approach and differential diagnosis for altered mental status after CAR-T therapy. Diagnosing HHV-6 encephalitis can be difficult in this patient population as altered mental status is common after CAR-T therapy and may be attributed to CAR-T-associated neurotoxicity.en_US
dc.description.urihttps://doi.org/10.1093/ofid/ofab470en_US
dc.description.urihttp://www.ncbi.nlm.nih.gov/pmc/articles/pmc8562470/en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofOpen Forum Infectious Diseasesen_US
dc.rights© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.en_US
dc.subject6 encephalitisen_US
dc.subjectCARen_US
dc.subjectHHVen_US
dc.subjectTen_US
dc.subjectcell therapyen_US
dc.subjectchimeric antigen receptor Ten_US
dc.subjecthuman herpesvirus 6en_US
dc.titleHHV-6 Encephalitis After Chimeric Antigen Receptor T-cell Therapy (CAR-T): 2 Case Reports and a Brief Review of the Literatureen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/ofid/ofab470
dc.identifier.pmid34738024
dc.source.volume8
dc.source.issue11
dc.source.beginpageofab470
dc.source.endpage
dc.source.countryUnited States


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