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    HHV-6 Encephalitis After Chimeric Antigen Receptor T-cell Therapy (CAR-T): 2 Case Reports and a Brief Review of the Literature

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    Author
    Rebechi, Melanie T
    Bork, Jacqueline T
    Riedel, David J
    Date
    2021-09-24
    Journal
    Open Forum Infectious Diseases
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/ofid/ofab470
    http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8562470/
    Abstract
    Human herpesvirus 6 (HHV-6) reactivation can occur in patients who are highly immunosuppressed, including those who have undergone hematopoietic stem cell transplantation (HSCT). HHV-6 encephalitis is a severe manifestation that is well described in the HSCT population. Chimeric antigen receptor T-cell (CAR-T) therapy is a novel cancer-directed immunotherapy that results in severe immunosuppression. Patients undergoing CAR-T therapy may be at risk for HHV-6 encephalitis, which can be difficult to distinguish from a common adverse effect of CAR-T therapy, neurotoxicity. Herein, we describe 2 patients diagnosed with HHV-6 encephalitis after CAR-T therapy and discuss the diagnostic approach and differential diagnosis for altered mental status after CAR-T therapy. Diagnosing HHV-6 encephalitis can be difficult in this patient population as altered mental status is common after CAR-T therapy and may be attributed to CAR-T-associated neurotoxicity.
    Rights/Terms
    © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
    Keyword
    6 encephalitis
    CAR
    HHV
    T
    cell therapy
    chimeric antigen receptor T
    human herpesvirus 6
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17084
    ae974a485f413a2113503eed53cd6c53
    10.1093/ofid/ofab470
    Scopus Count
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