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dc.contributor.authorHays, Allison G
dc.contributor.authorSchär, Michael
dc.contributor.authorBonanno, Gabriele
dc.contributor.authorLai, Shenghan
dc.contributor.authorMeyer, Joseph
dc.contributor.authorAfework, Yohannes
dc.contributor.authorSteinberg, Angela
dc.contributor.authorStradley, Samuel
dc.contributor.authorGerstenblith, Gary
dc.contributor.authorWeiss, Robert G
dc.date.accessioned2021-11-03T18:49:05Z
dc.date.available2021-11-03T18:49:05Z
dc.date.issued2021-10-15
dc.identifier.urihttp://hdl.handle.net/10713/17057
dc.description.abstractAims: Inflammation plays a critical role in the pathogenesis of coronary artery disease (CAD), however the impact of anti-inflammatory therapies to reduce those processes which promote atherosclerosis in CAD patients is unknown. We aimed to test the hypothesis that anti-inflammatory approaches improve impaired coronary endothelial function (CEF), a driver of coronary atherosclerosis, in stable CAD patients. Methods and Results: We performed a single-center, randomized, placebo-controlled, double-blinded trial to assess whether low dose methotrexate (MTX), low dose colchicine (LDC), and/or their combination (MTX+LDC), improves CEF using non-invasive MRI measures in patients with stable CAD (N = 94). The primary endpoint was the MRI-detected change in coronary cross-sectional area from rest to isometric handgrip exercise (IHE), a predominantly nitric oxide-dependent endothelial dependent stressor. Coronary and systemic endothelial endpoints, and serum inflammatory markers, were collected at baseline, 8 and 24 weeks. Anti-inflammatory study drugs were well-tolerated. There were no significant differences in any of the CEF parameters among the four groups (MTX, LDC, MTX+LDC, placebo) at 8 or 24 weeks. Serum markers of inflammation and systemic endothelial function measures were also not significantly different among the groups. Conclusion: This is the first study to examine the effects of the anti-inflammatory approaches using MTX, LDC, and/or the combination in stable CAD patients on CEF, a marker of vascular health and the primary endpoint of the study. Although these anti-inflammatory approaches were relatively well-tolerated, they did not improve coronary endothelial function in patients with stable CAD. Clinical Trial Registration: www.clinicaltrials.gov, identifier: NCT02366091.en_US
dc.description.urihttps://doi.org/10.3389/fcvm.2021.728654en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Cardiovascular Medicineen_US
dc.rightsCopyright © 2021 Hays, Schär, Bonanno, Lai, Meyer, Afework, Steinberg, Stradley, Gerstenblith and Weiss.en_US
dc.subjectcoronary artery diseaseen_US
dc.subjectcoronary endothelial functionen_US
dc.subjectflow mediated dilatationen_US
dc.subjectinflammationen_US
dc.subjectmagnetic resonance imagingen_US
dc.titleRandomized Trial of Anti-inflammatory Medications and Coronary Endothelial Dysfunction in Patients With Stable Coronary Disease.en_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fcvm.2021.728654
dc.identifier.pmid34722661
dc.source.volume8
dc.source.beginpage728654
dc.source.endpage
dc.source.countrySwitzerland


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