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    The Nucleoskeleton: Crossroad of Mechanotransduction in Skeletal Muscle

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    Author
    Iyer, Shama R
    Folker, Eric S
    Lovering, Richard M
    Date
    2021-10-15
    Journal
    Frontiers in Physiology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fphys.2021.724010
    Abstract
    Intermediate filaments (IFs) are a primary structural component of the cytoskeleton extending throughout the muscle cell (myofiber). Mechanotransduction, the process by which mechanical force is translated into a biochemical signal to activate downstream cellular responses, is crucial to myofiber function. Mechanical forces also act on the nuclear cytoskeleton, which is integrated with the myofiber cytoskeleton by the linker of the nucleoskeleton and cytoskeleton (LINC) complexes. Thus, the nucleus serves as the endpoint for the transmission of force through the cell. The nuclear lamina, a dense meshwork of lamin IFs between the nuclear envelope and underlying chromatin, plays a crucial role in responding to mechanical input; myofibers constantly respond to mechanical perturbation via signaling pathways by activation of specific genes. The nucleus is the largest organelle in cells and a master regulator of cell homeostasis, thus an understanding of how it responds to its mechanical environment is of great interest. The importance of the cell nucleus is magnified in skeletal muscle cells due to their syncytial nature and the extreme mechanical environment that muscle contraction creates. In this review, we summarize the bidirectional link between the organization of the nucleoskeleton and the contractile features of skeletal muscle as they relate to muscle function.
    Rights/Terms
    Copyright © 2021 Iyer, Folker and Lovering.
    Keyword
    aging
    intermediate filaments
    lamins
    mechanotransduction
    muscle disease
    nucleus
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17053
    ae974a485f413a2113503eed53cd6c53
    10.3389/fphys.2021.724010
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