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dc.contributor.authorCavaletti, Guido
dc.contributor.authorMarmiroli, Paola
dc.contributor.authorRenn, Cynthia L.
dc.contributor.authorDorsey, Susan G.
dc.contributor.authorSerra, Maria Pina
dc.contributor.authorQuartu, Marina
dc.contributor.authorMeregalli, Cristina
dc.date.accessioned2021-10-28T19:17:13Z
dc.date.available2021-10-28T19:17:13Z
dc.date.issued2021-10-19
dc.identifier.urihttp://hdl.handle.net/10713/17013
dc.description.abstractChemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most frequent side effects of antineoplastic treatment, particularly of lung, breast, prostate, gastrointestinal, and germinal cancers, as well as of different forms of leukemia, lymphoma, and multiple myeloma. Currently, no effective therapies are available for CIPN prevention, and symptomatic treatment is frequently ineffective; thus, several clinical trials are addressing this unmet clinical need. Among possible pharmacological treatments of CIPN, modulation of the endocannabinoid system might be particularly promising, especially in those CIPN types where analgesia and neuroinflammation modulation might be beneficial. In fact, several clinical trials are ongoing with the specific aim to better investigate the changes in endocannabinoid levels induced by systemic chemotherapy and the possible role of endocannabinoid system modulation to provide relief from CIPN symptoms, a hypothesis supported by preclinical evidence but never consistently demonstrated in patients. Interestingly, endocannabinoid system modulation might be one of the mechanisms at the basis of the reported efficacy of exercise and physical therapy in CIPN patients. This possible virtuous interplay will be discussed in this review. © 2021, The Author(s).en_US
dc.description.sponsorshipUniversità degli Studi di Milano-Bicoccaen_US
dc.description.urihttps://doi.org/10.1007/s13311-021-01127-1en_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofNeurotherapeuticsen_US
dc.subjectCannabinoid receptorsen_US
dc.subjectChemotherapyen_US
dc.subjectEndocannabinoid systemen_US
dc.subjectNeuropathyen_US
dc.subjectTreatmenten_US
dc.titleCannabinoids: an Effective Treatment for Chemotherapy-Induced Peripheral Neurotoxicity?en_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s13311-021-01127-1


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