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    Cannabinoids: an Effective Treatment for Chemotherapy-Induced Peripheral Neurotoxicity?

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    Author
    Cavaletti, Guido
    Marmiroli, Paola
    Renn, Cynthia L.
    Dorsey, Susan G.
    Serra, Maria Pina
    Quartu, Marina
    Meregalli, Cristina
    Date
    2021-10-19
    Journal
    Neurotherapeutics
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1007/s13311-021-01127-1
    Abstract
    Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the most frequent side effects of antineoplastic treatment, particularly of lung, breast, prostate, gastrointestinal, and germinal cancers, as well as of different forms of leukemia, lymphoma, and multiple myeloma. Currently, no effective therapies are available for CIPN prevention, and symptomatic treatment is frequently ineffective; thus, several clinical trials are addressing this unmet clinical need. Among possible pharmacological treatments of CIPN, modulation of the endocannabinoid system might be particularly promising, especially in those CIPN types where analgesia and neuroinflammation modulation might be beneficial. In fact, several clinical trials are ongoing with the specific aim to better investigate the changes in endocannabinoid levels induced by systemic chemotherapy and the possible role of endocannabinoid system modulation to provide relief from CIPN symptoms, a hypothesis supported by preclinical evidence but never consistently demonstrated in patients. Interestingly, endocannabinoid system modulation might be one of the mechanisms at the basis of the reported efficacy of exercise and physical therapy in CIPN patients. This possible virtuous interplay will be discussed in this review. © 2021, The Author(s).
    Sponsors
    Università degli Studi di Milano-Bicocca
    Keyword
    Cannabinoid receptors
    Chemotherapy
    Endocannabinoid system
    Neuropathy
    Treatment
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/17013
    ae974a485f413a2113503eed53cd6c53
    10.1007/s13311-021-01127-1
    Scopus Count
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