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dc.contributor.authorMaisonnasse, Pauline
dc.contributor.authorAldon, Yoann
dc.contributor.authorMarc, Aurélien
dc.contributor.authorMarlin, Romain
dc.contributor.authorDereuddre-Bosquet, Nathalie
dc.contributor.authorKuzmina, Natalia A
dc.contributor.authorFreyn, Alec W
dc.contributor.authorSnitselaar, Jonne L
dc.contributor.authorGonçalves, Antonio
dc.contributor.authorCaniels, Tom G
dc.contributor.authorBurger, Judith A
dc.contributor.authorPoniman, Meliawati
dc.contributor.authorBontjer, Ilja
dc.contributor.authorChesnais, Virginie
dc.contributor.authorDiry, Ségolène
dc.contributor.authorIershov, Anton
dc.contributor.authorRonk, Adam J
dc.contributor.authorJangra, Sonia
dc.contributor.authorRathnasinghe, Raveen
dc.contributor.authorBrouwer, Philip J M
dc.contributor.authorBijl, Tom P L
dc.contributor.authorvan Schooten, Jelle
dc.contributor.authorBrinkkemper, Mitch
dc.contributor.authorLiu, Hejun
dc.contributor.authorYuan, Meng
dc.contributor.authorMire, Chad E
dc.contributor.authorvan Breemen, Mariëlle J
dc.contributor.authorContreras, Vanessa
dc.contributor.authorNaninck, Thibaut
dc.contributor.authorLemaître, Julien
dc.contributor.authorKahlaoui, Nidhal
dc.contributor.authorRelouzat, Francis
dc.contributor.authorChapon, Catherine
dc.contributor.authorHo Tsong Fang, Raphaël
dc.contributor.authorMcDanal, Charlene
dc.contributor.authorOsei-Twum, Mary
dc.contributor.authorSt-Amant, Natalie
dc.contributor.authorGagnon, Luc
dc.contributor.authorMontefiori, David C
dc.contributor.authorWilson, Ian A
dc.contributor.authorGinoux, Eric
dc.contributor.authorde Bree, Godelieve J
dc.contributor.authorGarcía-Sastre, Adolfo
dc.contributor.authorSchotsaert, Michael
dc.contributor.authorCoughlan, Lynda
dc.contributor.authorBukreyev, Alexander
dc.contributor.authorvan der Werf, Sylvie
dc.contributor.authorGuedj, Jérémie
dc.contributor.authorSanders, Rogier W
dc.contributor.authorvan Gils, Marit J
dc.contributor.authorLe Grand, Roger
dc.date.accessioned2021-10-28T18:11:34Z
dc.date.available2021-10-28T18:11:34Z
dc.date.issued2021-10-20
dc.identifier.urihttp://hdl.handle.net/10713/17005
dc.description.abstractEffective treatments against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) are urgently needed. Monoclonal antibodies have shown promising results in patients. Here, we evaluate the in vivo prophylactic and therapeutic effect of COVA1-18, a neutralizing antibody highly potent against the B.1.1.7 isolate. In both prophylactic and therapeutic settings, SARS-CoV-2 remains undetectable in the lungs of treated hACE2 mice. Therapeutic treatment also causes a reduction in viral loads in the lungs of Syrian hamsters. When administered at 10 mg kg-1 one day prior to a high dose SARS-CoV-2 challenge in cynomolgus macaques, COVA1-18 shows very strong antiviral activity in the upper respiratory compartments. Using a mathematical model, we estimate that COVA1-18 reduces viral infectivity by more than 95% in these compartments, preventing lymphopenia and extensive lung lesions. Our findings demonstrate that COVA1-18 has a strong antiviral activity in three preclinical models and could be a valuable candidate for further clinical evaluation.en_US
dc.description.urihttps://doi.org/10.1038/s41467-021-26354-0en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofNature Communicationsen_US
dc.rights© 2021. The Author(s).en_US
dc.titleCOVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical modelsen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41467-021-26354-0
dc.identifier.pmid34671037
dc.source.volume12
dc.source.issue1
dc.source.beginpage6097
dc.source.endpage
dc.source.countryEngland


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