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dc.contributor.authorLi, Zhihui
dc.contributor.authorWang, Hongbing
dc.date.accessioned2021-10-28T17:39:27Z
dc.date.available2021-10-28T17:39:27Z
dc.date.issued2021-10-15
dc.identifier.urihttp://hdl.handle.net/10713/17001
dc.description.abstractCitrate is a crucial energy sensor that plays a central role in cellular metabolic homeostasis. The solute carrier family 13 member 5 (SLC13A5), a sodium-coupled citrate transporter highly expressed in the mammalian liver with relatively low levels in the testis and brain, imports citrate from extracellular spaces into the cells. The perturbation of SLC13A5 expression and/or activity is associated with non-alcoholic fatty liver disease, obesity, insulin resistance, cell proliferation, and early infantile epileptic encephalopathy. SLC13A5 has been proposed as a promising therapeutic target for the treatment of these metabolic disorders. In the liver, the inductive expression of SLC13A5 has been linked to several xenobiotic receptors such as the pregnane X receptor and the aryl hydrocarbon receptor as well as certain hormonal and nutritional stimuli. Nevertheless, in comparison to the heightened interest in understanding the biological function and clinical relevance of SLC13A5, studies focusing on the regulatory mechanisms of SLC13A5 expression are relatively limited. In this review, we discuss the current advances in our understanding of the molecular mechanisms by which the expression of SLC13A5 is regulated. We expect this review will provide greater insights into the regulation of the SLC13A5 gene transcription and the signaling pathways involved therein.en_US
dc.description.urihttps://doi.org/10.3390/metabo11100706en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofMetabolitesen_US
dc.subjectSLC13A5en_US
dc.subjectaryl hydrocarbon receptoren_US
dc.subjectpregnane X receptoren_US
dc.subjecttranscriptional regulationen_US
dc.subjectxenobiotic receptoren_US
dc.titleMolecular Mechanisms of the SLC13A5 Gene Transcriptionen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/metabo11100706
dc.identifier.pmid34677420
dc.source.volume11
dc.source.issue10
dc.source.countrySwitzerland


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