• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Characterization of the pathogenesis of bovine immunodeficiency-like virus (BIV) and BIV/bovine leukemia virus (BLV) infected calves

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Find Full text
    Author
    O'Neill, Timothy Patrick
    Advisor
    Eiseman, Julie L.
    Date
    1993
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    BIV is a lentivirus which is structurally, antigenically and molecularly related to the Human Immunodeficiency Virus-1 (HIV-1), the causative agent of AIDS in man. The early reports associated BIV infection with persistent lymphocytosis, generalized lymphadenopathy and wasting disease. However, controlled studies to define the pathogenesis associated with BIV infection in cattle, are needed. Additionally, the effects of BIV in association with other bovine retroviruses have yet to be reported. Therefore, a study was undertaken to define the pathogenesis of BIV or BIV/BLV infection in calves. Holstein calves, including three BIV inoculated, two BIV/BLV inoculated and four sham inoculated controls were followed from 0-18 months post inoculation (P.I.). Clinical abnormalities in BIV animals were early periodic lymphocytosis and in BIV/BLV, sustained lymphocytosis, periodic fever and diarrhea in BIV calves, lymphadenopathy at 45-60 days P.I. in both BIV and BIV/BLV inoculated, lymphoid depletion at 8 months P.I. with immunocytochemical detection of virus, and depression of lymphocyte blastogenesis assays at multiple time points in both BIV and BIV/BLV inoculated. Additionally, increases in percent circulating CD4+ cells in BIV and BIV/BLV infected calves were observed at 7, 10 and 18 months by flow cytometry, however, increases in absolute numbers of CD4+ cells were present, only in BIV/BLV animals. Serum immunoglobulin G levels were elevated in BIV infected animals, only. In vivo responses to PPD delayed-type hypersensitivity were increased in both BIV and BIV/BLV infected. Histopathology at eighteen months revealed mild lymphoid hyperplasia in peripheral lymph nodes of BIV infected and marked hyperplasia in BIV/BLV infected, with immunocytochemical detection of virus antigen. In the brains of BIV and BIV/BLV infected animals there were scattered perivascular cuffs of inflammatory cells. Immunocytochemically BIV antigen was localized in the cortex and midbrain. The results of this study suggest that, BIV alone or in combination with BLV cause transient alterations in immune function as assayed by in vitro and in vivo methods, produces lesions in lymphoid tissues and the CNS. The clinical and pathologic features of BIV infection share similarities with other lentiviral infections of other domestic animals.
    Description
    University of Maryland, Baltimore. Ph.D. 1993
    Keyword
    Health Sciences, Pathology
    Health Sciences, Immunology
    Immunodeficiency Virus, Bovine--pathogenicity
    Leukemia Virus, Bovine--pathogenicity
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/1698
    Collections
    Theses and Dissertations All Schools
    Theses and Dissertations School of Medicine

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.