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dc.contributor.authorSalerno-Gonçalves, Rosângela
dc.contributor.authorRezwan, Tasmia
dc.contributor.authorLuo, David
dc.contributor.authorTettelin, Hervé
dc.contributor.authorSztein, Marcelo B.
dc.date.accessioned2021-10-21T14:09:54Z
dc.date.available2021-10-21T14:09:54Z
dc.date.issued2021-10-01
dc.identifier.urihttp://hdl.handle.net/10713/16900
dc.description.abstractMucosal-associated invariant T (MAIT) cells are an innate-like population of T cells that display a TCR Vα7.2+ CD161+ phenotype and are restricted by the nonclassical MHC-related molecule 1 (MR1). Although B cells control MAIT cell development and function, little is known about the mechanisms underlying their interaction(s). Here, we report, for the first time, that during Salmonella enterica serovar Typhi (S. Typhi) infection, HLA-G expression on B cells downregulates IFN-γ production by MAIT cells. In contrast, blocking HLA-G expression on S. Typhi-infected B cells increases IFN-γ production by MAIT cells. After interacting with MAIT cells, kinetic studies show that B cells upregulate HLA-G expression and downregulate the inhibitory HLA-G receptor CD85j on MAIT cells resulting in their loss. These results provide a new role for HLA-G as a negative feedback loop by which B cells control MAIT cell responses to antigens.en_US
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseasesen_US
dc.description.urihttps://doi.org/10.3389/fimmu.2021.728685en_US
dc.language.isoenen_US
dc.publisherFrontiers Media SAen_US
dc.relation.ispartofFrontiers in Immunologyen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHLA-Gen_US
dc.subjectMAIT cellsen_US
dc.subjectS. Typhien_US
dc.subjecthumanen_US
dc.subjectintestineen_US
dc.titleB Cells Control Mucosal-Associated Invariant T Cell Responses to Salmonella enterica Serovar Typhi Infection Through the CD85j HLA-G Receptoren_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fimmu.2021.728685
dc.identifier.pmid34659215
dc.source.volume12


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