B Cells Control Mucosal-Associated Invariant T Cell Responses to Salmonella enterica Serovar Typhi Infection Through the CD85j HLA-G Receptor
Date
2021-10-01Journal
Frontiers in ImmunologyPublisher
Frontiers Media SAType
Article
Metadata
Show full item recordAbstract
Mucosal-associated invariant T (MAIT) cells are an innate-like population of T cells that display a TCR Vα7.2+ CD161+ phenotype and are restricted by the nonclassical MHC-related molecule 1 (MR1). Although B cells control MAIT cell development and function, little is known about the mechanisms underlying their interaction(s). Here, we report, for the first time, that during Salmonella enterica serovar Typhi (S. Typhi) infection, HLA-G expression on B cells downregulates IFN-γ production by MAIT cells. In contrast, blocking HLA-G expression on S. Typhi-infected B cells increases IFN-γ production by MAIT cells. After interacting with MAIT cells, kinetic studies show that B cells upregulate HLA-G expression and downregulate the inhibitory HLA-G receptor CD85j on MAIT cells resulting in their loss. These results provide a new role for HLA-G as a negative feedback loop by which B cells control MAIT cell responses to antigens.Sponsors
National Institute of Allergy and Infectious DiseasesIdentifier to cite or link to this item
http://hdl.handle.net/10713/16900ae974a485f413a2113503eed53cd6c53
10.3389/fimmu.2021.728685
Scopus Count
Collections
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/
Related articles
- Human mucosal-associated invariant T (MAIT) cells possess capacity for B cell help.
- Authors: Bennett MS, Trivedi S, Iyer AS, Hale JS, Leung DT
- Issue date: 2017 Nov
- Age-Associated Heterogeneity of Ty21a-Induced T Cell Responses to HLA-E Restricted <i>Salmonella</i> Typhi Antigen Presentation.
- Authors: Rudolph ME, McArthur MA, Magder LS, Barnes RS, Chen WH, Sztein MB
- Issue date: 2019
- HLA class I molecules regulate IFN-gamma production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j.
- Authors: Morel E, Bellón T
- Issue date: 2008 Aug 15
- Salmonella enterica serovar Typhi exposure elicits ex vivo cell-type-specific epigenetic changes in human gut cells.
- Authors: Sztein MB, Bafford AC, Salerno-Goncalves R
- Issue date: 2020 Aug 12
- MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression.
- Authors: Shaler CR, Choi J, Rudak PT, Memarnejadian A, Szabo PA, Tun-Abraham ME, Rossjohn J, Corbett AJ, McCluskey J, McCormick JK, Lantz O, Hernandez-Alejandro R, Haeryfar SMM
- Issue date: 2017 Jun