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dc.contributor.authorRodríguez, Cristina
dc.contributor.authorChen, Anderson
dc.contributor.authorRivera, José A
dc.contributor.authorMohr, Manuel A
dc.contributor.authorLiang, Yajie
dc.contributor.authorNatan, Ryan G
dc.contributor.authorSun, Wenzhi
dc.contributor.authorMilkie, Daniel E
dc.contributor.authorBifano, Thomas G
dc.contributor.authorChen, Xiaoke
dc.contributor.authorJi, Na
dc.date.accessioned2021-10-19T18:34:27Z
dc.date.available2021-10-19T18:34:27Z
dc.date.issued2021-10-04
dc.identifier.urihttp://hdl.handle.net/10713/16879
dc.description.abstractUnderstanding complex biological systems requires visualizing structures and processes deep within living organisms. We developed a compact adaptive optics module and incorporated it into two- and three-photon fluorescence microscopes, to measure and correct tissue-induced aberrations. We resolved synaptic structures in deep cortical and subcortical areas of the mouse brain, and demonstrated high-resolution imaging of neuronal structures and somatosensory-evoked calcium responses in the mouse spinal cord at great depths in vivo.en_US
dc.description.urihttps://doi.org/10.1038/s41592-021-01279-0en_US
dc.description.urihttps://www.biorxiv.org/content/10.1101/2020.11.25.397968v1en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofNature Methodsen_US
dc.rights© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.en_US
dc.subjectadaptive optics moduleen_US
dc.subjectdeep tissue imagingen_US
dc.subjectmultiphoton imagingen_US
dc.subject.meshIntravital Microscopy--methodsen_US
dc.subject.meshMiceen_US
dc.titleAn adaptive optics module for deep tissue multiphoton imaging in vivoen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/s41592-021-01279-0
dc.identifier.pmid34608309
dc.source.volume18
dc.source.issue10
dc.source.beginpage1259
dc.source.endpage1264
dc.source.countryUnited States


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