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dc.contributor.authorGuimarães Alves, Ana Cecília
dc.contributor.authorSukow, Natalie Mary
dc.contributor.authorAdelman Cipolla, Gabriel
dc.contributor.authorMendes, Marla
dc.contributor.authorLeal, Thiago P
dc.contributor.authorPetzl-Erler, Maria Luiza
dc.contributor.authorLehtonen Rodrigues Souza, Ricardo
dc.contributor.authorRainha de Souza, Ilíada
dc.contributor.authorSanchez, Cesar
dc.contributor.authorSantolalla, Meddly
dc.contributor.authorLoesch, Douglas
dc.contributor.authorDean, Michael
dc.contributor.authorMachado, Moara
dc.contributor.authorMoon, Jee-Young
dc.contributor.authorKaplan, Robert
dc.contributor.authorNorth, Kari E
dc.contributor.authorWeiss, Scott
dc.contributor.authorBarreto, Mauricio L
dc.contributor.authorLima-Costa, M Fernanda
dc.contributor.authorGuio, Heinner
dc.contributor.authorCáceres, Omar
dc.contributor.authorPadilla, Carlos
dc.contributor.authorTarazona-Santos, Eduardo
dc.contributor.authorMata, Ignacio F
dc.contributor.authorDieguez, Elena
dc.contributor.authorRaggio, Víctor
dc.contributor.authorLescano, Andres
dc.contributor.authorTumas, Vitor
dc.contributor.authorBorges, Vanderci
dc.contributor.authorFerraz, Henrique B
dc.contributor.authorRieder, Carlos R
dc.contributor.authorSchumacher-Schuh, Artur
dc.contributor.authorSantos-Lobato, Bruno L
dc.contributor.authorChana-Cuevas, Pedro
dc.contributor.authorFernandez, William
dc.contributor.authorArboleda, Gonzalo
dc.contributor.authorArboleda, Humberto
dc.contributor.authorArboleda-Bustos, Carlos E
dc.contributor.authorO'Connor, Timothy D
dc.contributor.authorBeltrame, Marcia Holsbach
dc.contributor.authorBorda, Victor
dc.date.accessioned2021-10-15T18:38:48Z
dc.date.available2021-10-15T18:38:48Z
dc.date.issued2021-09-22
dc.identifier.urihttp://hdl.handle.net/10713/16856
dc.description.abstractIn adulthood, the ability to digest lactose, the main sugar present in milk of mammals, is a phenotype (lactase persistence) observed in historically herder populations, mainly Northern Europeans, Eastern Africans, and Middle Eastern nomads. As the -13910∗T allele in the MCM6 gene is the most well-characterized allele responsible for the lactase persistence phenotype, the -13910C > T (rs4988235) polymorphism is commonly evaluated in lactase persistence studies. Lactase non-persistent adults may develop symptoms of lactose intolerance when consuming dairy products. In the Americas, there is no evidence of the consumption of these products until the arrival of Europeans. However, several American countries' dietary guidelines recommend consuming dairy for adequate human nutrition and health promotion. Considering the extensive use of dairy and the complex ancestry of Pan-American admixed populations, we studied the distribution of -13910C > T lactase persistence genotypes and its flanking haplotypes of European origin in 7,428 individuals from several Pan-American admixed populations. We found that the -13910∗T allele frequency in Pan-American admixed populations is directly correlated with allele frequency of the European sources. Moreover, we did not observe any overrepresentation of European haplotypes in the -13910C > T flanking region, suggesting no selective pressure after admixture in the Americas. Finally, considering the dominant effect of the -13910∗T allele, our results indicate that Pan-American admixed populations are likely to have higher frequency of lactose intolerance, suggesting that general dietary guidelines deserve further evaluation across the continent.en_US
dc.description.urihttps://doi.org/10.3389/fgene.2021.671079en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Geneticsen_US
dc.rightsCopyright © 2021 Guimarães Alves, Sukow, Adelman Cipolla, Mendes, Leal, Petzl-Erler, Lehtonen Rodrigues Souza, Rainha de Souza, Sanchez, Santolalla, Loesch, Dean, Machado, Moon, Kaplan, North, Weiss, Barreto, Lima-Costa, Guio, Cáceres, Padilla, Tarazona-Santos, Mata, Dieguez, Raggio, Lescano, Tumas, Borges, Ferraz, Rieder, Schumacher-Schuh, Santos-Lobato, Chana-Cuevas, Fernandez, Arboleda, Arboleda, Arboleda-Bustos, O’Connor, Beltrame and Borda.en_US
dc.subjectLatin Americaen_US
dc.subjectMCM6 geneen_US
dc.subjectdairy consumptionen_US
dc.subjectlactose intoleranceen_US
dc.subjectnutrition policiesen_US
dc.subjectpopulation geneticsen_US
dc.subject–13910C > Ten_US
dc.titleTracing the Distribution of European Lactase Persistence Genotypes Along the Americasen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fgene.2021.671079
dc.identifier.pmid34630506
dc.source.volume12
dc.source.beginpage671079
dc.source.endpage
dc.source.countrySwitzerland


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