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    Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas

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    Author
    Guimarães Alves, Ana Cecília
    Sukow, Natalie Mary
    Adelman Cipolla, Gabriel
    Mendes, Marla
    Leal, Thiago P
    Petzl-Erler, Maria Luiza
    Lehtonen Rodrigues Souza, Ricardo
    Rainha de Souza, Ilíada
    Sanchez, Cesar
    Santolalla, Meddly
    Loesch, Douglas
    Dean, Michael
    Machado, Moara
    Moon, Jee-Young
    Kaplan, Robert
    North, Kari E
    Weiss, Scott
    Barreto, Mauricio L
    Lima-Costa, M Fernanda
    Guio, Heinner
    Cáceres, Omar
    Padilla, Carlos
    Tarazona-Santos, Eduardo
    Mata, Ignacio F
    Dieguez, Elena
    Raggio, Víctor
    Lescano, Andres
    Tumas, Vitor
    Borges, Vanderci
    Ferraz, Henrique B
    Rieder, Carlos R
    Schumacher-Schuh, Artur
    Santos-Lobato, Bruno L
    Chana-Cuevas, Pedro
    Fernandez, William
    Arboleda, Gonzalo
    Arboleda, Humberto
    Arboleda-Bustos, Carlos E
    O'Connor, Timothy D
    Beltrame, Marcia Holsbach
    Borda, Victor
    Show allShow less

    Date
    2021-09-22
    Journal
    Frontiers in Genetics
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fgene.2021.671079
    Abstract
    In adulthood, the ability to digest lactose, the main sugar present in milk of mammals, is a phenotype (lactase persistence) observed in historically herder populations, mainly Northern Europeans, Eastern Africans, and Middle Eastern nomads. As the -13910∗T allele in the MCM6 gene is the most well-characterized allele responsible for the lactase persistence phenotype, the -13910C > T (rs4988235) polymorphism is commonly evaluated in lactase persistence studies. Lactase non-persistent adults may develop symptoms of lactose intolerance when consuming dairy products. In the Americas, there is no evidence of the consumption of these products until the arrival of Europeans. However, several American countries' dietary guidelines recommend consuming dairy for adequate human nutrition and health promotion. Considering the extensive use of dairy and the complex ancestry of Pan-American admixed populations, we studied the distribution of -13910C > T lactase persistence genotypes and its flanking haplotypes of European origin in 7,428 individuals from several Pan-American admixed populations. We found that the -13910∗T allele frequency in Pan-American admixed populations is directly correlated with allele frequency of the European sources. Moreover, we did not observe any overrepresentation of European haplotypes in the -13910C > T flanking region, suggesting no selective pressure after admixture in the Americas. Finally, considering the dominant effect of the -13910∗T allele, our results indicate that Pan-American admixed populations are likely to have higher frequency of lactose intolerance, suggesting that general dietary guidelines deserve further evaluation across the continent.
    Rights/Terms
    Copyright © 2021 Guimarães Alves, Sukow, Adelman Cipolla, Mendes, Leal, Petzl-Erler, Lehtonen Rodrigues Souza, Rainha de Souza, Sanchez, Santolalla, Loesch, Dean, Machado, Moon, Kaplan, North, Weiss, Barreto, Lima-Costa, Guio, Cáceres, Padilla, Tarazona-Santos, Mata, Dieguez, Raggio, Lescano, Tumas, Borges, Ferraz, Rieder, Schumacher-Schuh, Santos-Lobato, Chana-Cuevas, Fernandez, Arboleda, Arboleda, Arboleda-Bustos, O’Connor, Beltrame and Borda.
    Keyword
    Latin America
    MCM6 gene
    dairy consumption
    lactose intolerance
    nutrition policies
    population genetics
    –13910C > T
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/16856
    ae974a485f413a2113503eed53cd6c53
    10.3389/fgene.2021.671079
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